Hongshan Guo
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Explore the profile of Hongshan Guo including associated specialties, affiliations and a list of published articles.
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Articles
36
Citations
3797
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Recent Articles
1.
Wen Z, Liu T, Xu X, Acharya N, Shen Z, Lu Y, et al.
Nat Commun
. 2025 Mar;
16(1):2362.
PMID: 40064918
Overcoming immunosuppression in the tumor microenvironment (TME) is crucial for developing novel cancer immunotherapies. Here, we report that IL-16 administration enhances the polarization of T helper 1 (Th1) cells by...
2.
Zhang L, Weiskittel T, Zhu Y, Xue D, Zhang H, Shen Y, et al.
Life Med
. 2025 Jan;
3(4):lnae032.
PMID: 39872864
Clinical and preclinical research has demonstrated that iPSC-derived NK (iNK) cells have a high therapeutic potential, yet poor understanding of the detailed process of their differentiation and their counterpart cell...
3.
Wang J, Ye F, Chai H, Jiang Y, Wang T, Ran X, et al.
Sci China Life Sci
. 2025 Jan;
PMID: 39792333
The applications of single-cell and spatial technologies in recent times have revolutionized the present understanding of cellular states and the cellular heterogeneity inherent in complex biological systems. These advancements offer...
4.
Hu Y, Zhang M, Yang T, Mo Z, Wei G, Jing R, et al.
N Engl J Med
. 2024 Apr;
390(16):1467-1480.
PMID: 38657244
Background: Patients with relapsed or refractory hematologic cancers have a poor prognosis. Chimeric antigen receptor (CAR) T-cell therapy as a bridge to allogeneic hematopoietic stem-cell transplantation (HSCT) has the potential...
5.
Zhang T, Jia H, Song T, Lv L, Gulhan D, Wang H, et al.
Genome Med
. 2023 Dec;
15(1):115.
PMID: 38111063
Identifying expressed somatic mutations from single-cell RNA sequencing data de novo is challenging but highly valuable. We propose RESA - Recurrently Expressed SNV Analysis, a computational framework to identify expressed...
6.
Guo H, Vuille J, Wittner B, Lachtara E, Hou Y, Lin M, et al.
Cell
. 2023 Jun;
186(13):2765-2782.e28.
PMID: 37327786
Cancer is characterized by hypomethylation-associated silencing of large chromatin domains, whose contribution to tumorigenesis is uncertain. Through high-resolution genome-wide single-cell DNA methylation sequencing, we identify 40 core domains that are...
7.
Fox D, Ebright R, Hong X, Russell H, Guo H, LaSalle T, et al.
NPJ Precis Oncol
. 2023 Mar;
7(1):25.
PMID: 36864091
Immune checkpoint blockade (ICB) has demonstrated efficacy in patients with melanoma, but many exhibit poor responses. Using single cell RNA sequencing of melanoma patient-derived circulating tumor cells (CTCs) and functional...
8.
TGF-β in the microenvironment induces a physiologically occurring immune-suppressive senescent state
Matsuda S, Revandkar A, Dubash T, Ravi A, Wittner B, Lin M, et al.
Cell Rep
. 2023 Feb;
42(3):112129.
PMID: 36821441
TGF-β induces senescence in embryonic tissues. Whether TGF-β in the hypoxic tumor microenvironment (TME) induces senescence in cancer and how the ensuing senescence-associated secretory phenotype (SASP) remodels the cellular TME...
9.
Zhang J, Liu Z, Guo H, Lin H, Wang H, Liang X, et al.
ACS Appl Mater Interfaces
. 2022 Apr;
14(17):19388-19396.
PMID: 35442619
Ethylene (CH) is an important product in carbon dioxide electroreduction (CORR) because of the essential role it plays in chemical industry. While several strategies have been proposed to tune the...
10.
Tan X, Wang X, Zhou T, Chen T, Liu Y, Ma C, et al.
Chemosphere
. 2022 Feb;
295:133929.
PMID: 35149017
It still remains a hotspot and great challenge to efficiently remove the nitrate nitrogen from high salt wastewater. Herein, a novel three dimensional porous bimetallic copper-nickel alloy electrode was fabricated...