Hongchang Qu
Overview
Explore the profile of Hongchang Qu including associated specialties, affiliations and a list of published articles.
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31
Citations
851
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Recent Articles
11.
Recknagel S, Bindl R, Kurz J, Wehner T, Schoengraf P, Ehrnthaller C, et al.
J Orthop Res
. 2011 Sep;
30(4):581-6.
PMID: 21922535
Confirming clinical evidence, we recently demonstrated that a blunt chest trauma considerably impaired fracture healing in rats, possibly via the interaction of posttraumatic systemic inflammation with local healing processes, the...
12.
Suetsugu-Maki R, Maki N, Fox T, Nakamura K, Cowper Solari R, Tomlinson C, et al.
Mol Vis
. 2011 May;
17:949-64.
PMID: 21541266
Purpose: To evaluate the effects of complement employing a mouse model for secondary cataract. Methods: The role of complement receptor C5a (CD88) was evaluated after cataract surgery in mice. An...
13.
Knerr P, Tzekou A, Ricklin D, Qu H, Chen H, van der Donk W, et al.
ACS Chem Biol
. 2011 Apr;
6(7):753-60.
PMID: 21520911
Disulfide bonds are essential for the structural stability and biological activity of many bioactive peptides. However, these bonds are labile to reducing agents, which can limit the therapeutic utility of...
14.
Subramanian H, Kashem S, Collington S, Qu H, Lambris J, Ali H
Mol Pharmacol
. 2011 Mar;
79(6):1005-13.
PMID: 21441599
Human mast cells express the G protein coupled receptor (GPCR) for C5a (CD88). Previous studies indicated that C5a could cause mast cell degranulation, at least in part, via a mechanism...
15.
Wu Y, Qu H, Sfyroera G, Tzekou A, Kay B, Nilsson B, et al.
J Immunol
. 2011 Feb;
186(7):4269-77.
PMID: 21339361
Exposure of nonself surfaces such as those of biomaterials or transplanted cells and organs to host blood frequently triggers innate immune responses, thereby affecting both their functionality and tolerability. Activation...
16.
Cai M, Liu Z, Qu H, Fan H, Zheng Z, Hruby V
Eur J Pharmacol
. 2011 Feb;
660(1):188-93.
PMID: 21315067
Peptides serve as effective drugs and contrast agents in the clinic today. However the inherent drawbacks of peptide structures can limit their efficacy as drugs. To overcome this we have...
17.
Liang S, Krauss J, Domon H, McIntosh M, Hosur K, Qu H, et al.
J Immunol
. 2010 Dec;
186(2):869-77.
PMID: 21149611
The C5a anaphylatoxin receptor (C5aR; CD88) is activated as part of the complement cascade and exerts important inflammatory, antimicrobial, and regulatory functions, at least in part, via crosstalk with TLRs....
18.
Qu H, Magotti P, Ricklin D, Wu E, Kourtzelis I, Wu Y, et al.
Mol Immunol
. 2010 Nov;
48(4):481-9.
PMID: 21067811
Compstatin is a 13-residue disulfide-bridged peptide that inhibits a key step in the activation of the human complement system. Compstatin and its derivatives have shown great promise for the treatment...
19.
Kourtzelis I, Markiewski M, Doumas M, Rafail S, Kambas K, Mitroulis I, et al.
Blood
. 2010 Apr;
116(4):631-9.
PMID: 20424189
Thrombosis is a common complication of end-stage renal disease, particularly in patients on hemodialysis. Although substantial progress has been made in preventing thrombotic complications in various other groups of patients,...
20.
Qu H, Ricklin D, Lambris J
Mol Immunol
. 2009 Oct;
47(2-3):185-95.
PMID: 19800693
As a key part of the innate immune system, complement plays an important role not only in defending against invading pathogens but also in many other biological processes. Inappropriate or...