Kurt M Reichermeier
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Explore the profile of Kurt M Reichermeier including associated specialties, affiliations and a list of published articles.
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7
Citations
264
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Recent Articles
1.
Li J, Purser N, Liwocha J, Scott D, Byers H, Steigenberger B, et al.
Mol Cell
. 2024 Feb;
84(7):1304-1320.e16.
PMID: 38382526
Cullin-RING ligases (CRLs) ubiquitylate specific substrates selected from other cellular proteins. Substrate discrimination and ubiquitin transferase activity were thought to be strictly separated. Substrates are recognized by substrate receptors, such...
2.
Wang K, Reichermeier K, Liu X
Protein Sci
. 2021 Aug;
30(11):2338-2345.
PMID: 34459035
Through catalyzing the ubiquitination of key regulatory proteins, cullin-RING ubiquitin ligases (CRLs) play essential biological roles and their activities are controlled by multiple mechanisms including neddylation, the conjugation of NEDD8...
3.
Reichermeier K, Straube R, Reitsma J, Sweredoski M, Rose C, Moradian A, et al.
Mol Cell
. 2020 Jan;
77(5):1092-1106.e9.
PMID: 31973889
Co-opting Cullin4 RING ubiquitin ligases (CRL4s) to inducibly degrade pathogenic proteins is emerging as a promising therapeutic strategy. Despite intense efforts to rationally design degrader molecules that co-opt CRL4s, much...
4.
Chen S, Jang G, Huttenhain R, Gordon D, Du D, Newton B, et al.
EMBO J
. 2018 Sep;
37(18).
PMID: 30166453
Multi-subunit cullin-RING ligases (CRLs) are the largest family of ubiquitin E3 ligases in humans. CRL activity is tightly regulated to prevent unintended substrate degradation or autocatalytic degradation of CRL subunits....
5.
Verma R, Reichermeier K, Burroughs A, Oania R, Reitsma J, Aravind L, et al.
Nature
. 2018 Apr;
557(7705):446-451.
PMID: 29632312
Ribosomal surveillance pathways scan for ribosomes that are transiently paused or terminally stalled owing to structural elements in mRNAs or nascent chain sequences. Some stalls in budding yeast are sensed...
6.
Reitsma J, Liu X, Reichermeier K, Moradian A, Sweredoski M, Hess S, et al.
Cell
. 2017 Nov;
171(6):1326-1339.e14.
PMID: 29103612
SCF (Skp1-Cullin-F-box) ubiquitin ligases comprise several dozen modular enzymes that have diverse roles in biological regulation. SCF enzymes share a common catalytic core containing Cul1⋅Rbx1, which is directed toward different...
7.
Mosadeghi R, Reichermeier K, Winkler M, Schreiber A, Reitsma J, Zhang Y, et al.
Elife
. 2016 Apr;
5.
PMID: 27031283
The COP9-Signalosome (CSN) regulates cullin-RING ubiquitin ligase (CRL) activity and assembly by cleaving Nedd8 from cullins. Free CSN is autoinhibited, and it remains unclear how it becomes activated. We combine...