Holger Bierhoff
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Explore the profile of Holger Bierhoff including associated specialties, affiliations and a list of published articles.
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26
Citations
1132
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Recent Articles
11.
Kosan C, Heidel F, Godmann M, Bierhoff H
Cells
. 2018 Dec;
7(12).
PMID: 30501028
In complex organisms, stem cells are key for tissue maintenance and regeneration. Adult stem cells replenish continuously dividing tissues of the epithelial and connective types, whereas in non-growing muscle and...
12.
Sharifi S, Bierhoff H
Annu Rev Biochem
. 2018 Mar;
87:51-73.
PMID: 29589958
Ribosome biogenesis is a complex and highly energy-demanding process that requires the concerted action of all three nuclear RNA polymerases (Pol I-III) in eukaryotes. The three largest ribosomal RNAs (rRNAs)...
13.
Brocks D, Schmidt C, Daskalakis M, Jang H, Shah N, Li D, et al.
Nat Genet
. 2017 Oct;
49(11):1661.
PMID: 29074949
This corrects the article DOI: 10.1038/ng.3889.
14.
Bierhoff H
Methods Mol Biol
. 2017 Oct;
1686:241-250.
PMID: 29030825
Long noncoding RNAs (lncRNAs) have important roles in shaping chromatin by targeting chromatin-modifying enzymes to distinct genomic sites. This section covers two methods to analyze lncRNA-protein interactions. The RNA-protein pull-down...
15.
Brocks D, Schmidt C, Daskalakis M, Jang H, Shah N, Li D, et al.
Nat Genet
. 2017 Jun;
49(7):1052-1060.
PMID: 28604729
Several mechanisms of action have been proposed for DNA methyltransferase and histone deacetylase inhibitors (DNMTi and HDACi), primarily based on candidate-gene approaches. However, less is known about their genome-wide transcriptional...
16.
Evsyukov V, Domanskyi A, Bierhoff H, Gispert S, Mustafa R, Schlaudraff F, et al.
Dis Model Mech
. 2017 Apr;
10(5):633-643.
PMID: 28360124
Genetic mutations underlying neurodegenerative disorders impair ribosomal DNA (rDNA) transcription suggesting that nucleolar dysfunction could be a novel pathomechanism in polyglutamine diseases and in certain forms of amyotrophic lateral sclerosis/frontotemporal...
17.
Zhao Z, Dammert M, Hoppe S, Bierhoff H, Grummt I
Nucleic Acids Res
. 2016 Jun;
44(17):8144-52.
PMID: 27257073
Attenuation of ribosome biogenesis in suboptimal growth environments is crucial for cellular homeostasis and genetic integrity. Here, we show that shutdown of rRNA synthesis in response to elevated temperature is...
18.
Zhao Z, Dammert M, Grummt I, Bierhoff H
Cell Rep
. 2016 Feb;
14(8):1876-82.
PMID: 26904956
The activity of rRNA genes (rDNA) is regulated by pathways that target the transcription machinery or alter the epigenetic state of rDNA. Previous work has established that downregulation of rRNA...
19.
Bierhoff H, Dammert M, Brocks D, Dambacher S, Schotta G, Grummt I
Mol Cell
. 2014 Apr;
54(4):675-82.
PMID: 24768537
A complex network of regulatory pathways links transcription to cell growth and proliferation. Here we show that cellular quiescence alters chromatin structure by promoting trimethylation of histone H4 at lysine...
20.
Kiryk A, Sowodniok K, Kreiner G, Rodriguez-Parkitna J, Sonmez A, Gorkiewicz T, et al.
Front Cell Neurosci
. 2013 Nov;
7:207.
PMID: 24273493
Decreased rRNA synthesis and nucleolar disruption, known as nucleolar stress, are primary signs of cellular stress associated with aging and neurodegenerative disorders. Silencing of rDNA occurs during early stages of...