Alexander Otto Eberhardt
Overview
Explore the profile of Alexander Otto Eberhardt including associated specialties, affiliations and a list of published articles.
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Articles
3
Citations
90
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Recent Articles
1.
Reducing the metabolic burden of rRNA synthesis promotes healthy longevity in Caenorhabditis elegans
Sharifi S, Chaudhari P, Martirosyan A, Eberhardt A, Witt F, Gollowitzer A, et al.
Nat Commun
. 2024 Feb;
15(1):1702.
PMID: 38402241
Ribosome biogenesis is initiated by RNA polymerase I (Pol I)-mediated synthesis of pre-ribosomal RNA (pre-rRNA). Pol I activity was previously linked to longevity, but the underlying mechanisms were not studied...
2.
Joshi G, Eberhardt A, Lange L, Winkler R, Hoffmann S, Kosan C, et al.
Cancers (Basel)
. 2020 Oct;
12(10).
PMID: 33081395
A major transcriptional output of cells is ribosomal RNA (rRNA), synthesized by RNA polymerase I (Pol I) from multicopy rRNA genes (rDNA). Constitutive silencing of an rDNA fraction by promoter...
3.
Kofuji S, Hirayama A, Eberhardt A, Kawaguchi R, Sugiura Y, Sampetrean O, et al.
Nat Cell Biol
. 2019 Aug;
21(8):1003-1014.
PMID: 31371825
In many cancers, high proliferation rates correlate with elevation of rRNA and tRNA levels, and nucleolar hypertrophy. However, the underlying mechanisms linking increased nucleolar transcription and tumorigenesis are only minimally...