Hoi Yee Chu
Overview
Explore the profile of Hoi Yee Chu including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
125
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0
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Recent Articles
1.
Chu H, Peng J, Mou Y, Wong A
Methods Mol Biol
. 2024 Nov;
2870:227-243.
PMID: 39543038
Numerous high-specificity Cas9 variants have been engineered for precision genome editing. These variants typically harbor multiple mutations designed to alter the Cas9-single guide RNA (sgRNA)-DNA complex interactions for reduced off-target...
2.
Mok C, Chu H, Lam W, Au S
Structure
. 2024 Jul;
32(10):1725-1736.e4.
PMID: 39032488
Cag type IV secretion system (CagT4SS) translocates oncoprotein cytotoxin-associated gene A (CagA) into host cells and plays a key role in the pathogenesis of Helicobacter pylori. The structure of the...
3.
Chu H, Fong J, Thean D, Zhou P, Fung F, Huang Y, et al.
Cell Syst
. 2024 Feb;
15(2):193-203.e6.
PMID: 38340729
A strategy to obtain the greatest number of best-performing variants with least amount of experimental effort over the vast combinatorial mutational landscape would have enormous utility in boosting resource producibility...
4.
Chan C, Wang B, Nan L, Huang X, Mao T, Chu H, et al.
Nat Biomed Eng
. 2024 Jan;
8(3):336.
PMID: 38267642
No abstract available.
5.
Chan C, Wang B, Nan L, Huang X, Mao T, Chu H, et al.
Nat Biomed Eng
. 2023 Nov;
8(3):291-309.
PMID: 37996617
Mapping mutations and discovering cellular determinants that cause the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to induce infected cells to form syncytia would facilitate the development...
6.
Fong J, Chu H, Zhou P, Wong A
Cell Syst
. 2023 May;
14(5):392-403.e4.
PMID: 37164010
Selecting the most suitable existing base editors and engineering new variants for installing specific base conversions with maximal efficiency and minimal undesired edits are pivotal for precise genome editing applications....
7.
Chu H, Wong A
Adv Genet (Hoboken)
. 2023 Jan;
2(4):2100038.
PMID: 36619853
Protein design plays an important role in recent medical advances from antibody therapy to vaccine design. Typically, exhaustive mutational screens or directed evolution experiments are used for the identification of...
8.
Thean D, Chu H, Fong J, Chan B, Zhou P, Kwok C, et al.
Nat Commun
. 2022 Apr;
13(1):2219.
PMID: 35468907
The genome-editing Cas9 protein uses multiple amino-acid residues to bind the target DNA. Considering only the residues in proximity to the target DNA as potential sites to optimise Cas9's activity,...
9.
Yuen C, Thean D, Chan B, Zhou P, Kwok C, Chu H, et al.
Nucleic Acids Res
. 2022 Jan;
50(3):1650-1660.
PMID: 35051997
The Cas9 nuclease from Staphylococcus aureus (SaCas9) holds great potential for use in gene therapy, and variants with increased fidelity have been engineered. However, we find that existing variants have...
10.
Xu F, Tong M, Tong C, Chan B, Chu H, Wong T, et al.
Cancer Res
. 2021 Oct;
81(24):6219-6232.
PMID: 34666996
Systematic testing of existing drugs and their combinations is an attractive strategy to exploit approved drugs for repurposing and identifying the best actionable treatment options. To expedite the search among...