Hideyo Takahashi
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Explore the profile of Hideyo Takahashi including associated specialties, affiliations and a list of published articles.
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Articles
82
Citations
233
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Recent Articles
1.
Kimura Y, Suga M, Nakamura K, Tabata H, Oshitari T, Natsugari H, et al.
Pharm Res
. 2024 Dec;
41(12):2363-2375.
PMID: 39695066
Purpose: Drug photodegradation is a matter of great concern because it can result in potency loss and adverse side effects. This study examines the light-induced degradation of dacarbazine catalyzed by...
2.
Takano R, Tanaka R, Nakamura K, Tabata H, Oshitari T, Natsugari H, et al.
Bioorg Med Chem Lett
. 2024 Jun;
110:129854.
PMID: 38914347
C9-methylated quazepam 1 was prepared, and its physicochemical properties were investigated. The atropisomers of 1 were isolated as (aR, aS) and (aS, aR) isomers. Their absolute configurations were determined based...
3.
Arita H, Tanaka R, Kikukawa S, Tomizawa T, Sakata H, Funada M, et al.
J Med Chem
. 2024 Jun;
67(12):10447-10463.
PMID: 38869493
In recent years, synthetic opioids have emerged as a predominant cause of drug-overdose-related fatalities, causing the "opioid crisis." To design safer therapeutic agents, we accidentally discovered μ-opioid receptor (MOR) antagonists...
4.
Suga M, Fukushima S, Makino K, Nakamura K, Tabata H, Oshitari T, et al.
J Org Chem
. 2024 Jun;
89(12):8836-8844.
PMID: 38836790
The photocatalytic synthesis of thermodynamically less-stable -alkenes has received considerable research attention in recent years. In this study, a recycling photoreactor was applied to the photoisomerization of -alkenes (cinnamamide and...
5.
Kasai S, Ogawa N, Takagi M, Takahashi Y, Makino K, Arita H, et al.
Biol Pharm Bull
. 2024 Apr;
47(4):872-877.
PMID: 38658360
The formalin test is one approach to studying acute pain in rodents. Similar to formalin, injection with glutamate and veratrine can also produce a nociceptive response. This study investigated whether...
6.
Okubo K, Kudo T, Yoshihara S, Nakabayashi Y, Nakauchi K, Tanaka A, et al.
Drug Metab Pharmacokinet
. 2023 Dec;
54:100537.
PMID: 38086197
We previously reported that repeated oral administration of vonoprazan (VPZ) followed by oral administration of proguanil (PG) in healthy adults increased blood concentration of PG and decreased blood concentration of...
7.
Nishimoto-Kusunose S, Hirakawa A, Tanaka A, Yoshizawa K, Makino K, Takahashi H, et al.
Steroids
. 2023 Jul;
198:109272.
PMID: 37468115
Allopregnanolone (AP) is a neurosteroid synthesized in the brain and a positive allosteric modulator of γ-aminobutyric acid (GABA) type A receptors. Some drugs possessing the aryloxypropanamine (AOPA) pharmacophore, such as...
8.
Chiba A, Tanaka R, Hotta M, Nakamura K, Makino K, Tabata H, et al.
Molecules
. 2023 Jun;
28(12).
PMID: 37375290
The stereochemical properties of -acyl-5-dibenzo[,]azepin-7(6)-ones (-), which inhibit potassium channels in T cells, were examined by freezing their conformational change due to 4-methyl substitution. -Acyl-5-dibenzo[,]azepin-7(6)-ones exist as pairs of enantiomers...
9.
Li Y, Ohtake C, Hotta M, Tabata H, Hirano K, Iida M, et al.
J Org Chem
. 2023 May;
88(11):7026-7037.
PMID: 37200001
In this study, the conformational properties of tertiary trifluoroacetamides in dibenzoazepine ( and ) and benzodiazepine ( and ) derivatives, which exist as equilibrated - and amide conformers in solution,...
10.
Tozawa K, Makino K, Tanaka Y, Nakamura K, Inagaki A, Tabata H, et al.
J Org Chem
. 2023 May;
88(11):6955-6961.
PMID: 37155937
Chiral sulfoxides are valuable in the fields of medicinal chemistry and organic synthesis. A recycle photoreactor utilizing the concept of deracemization, where a racemate is converted into a pure enantiomer,...