Hideki Enomoto
Overview
Explore the profile of Hideki Enomoto including associated specialties, affiliations and a list of published articles.
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Articles
47
Citations
3236
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Recent Articles
1.
Putra B, Ito K, Cirillo C, Sunardi M, Koseki H, Uesaka T, et al.
Dev Growth Differ
. 2023 Jul;
65(8):461-469.
PMID: 37452641
The enteric nervous system (ENS) regulates gut functions independently from the central nervous system (CNS) by its highly autonomic neural circuit that integrates diverse neuronal subtypes. Although several transcription factors...
2.
Sunardi M, Ito K, Sato Y, Uesaka T, Iwasaki M, Enomoto H
Cell Mol Gastroenterol Hepatol
. 2022 Dec;
15(6):1505-1524.
PMID: 36521661
Background & Aims: Hirschsprung disease (HSCR) is a congenital disorder characterized by the absence of the enteric nervous system (ENS). HSCR potentially involves multiple gene aberrations and displays complex patterns...
3.
Yoshioka Y, Tachibana Y, Uesaka T, Hioki H, Sato Y, Fukumoto T, et al.
Biochem Biophys Res Commun
. 2022 Apr;
608:66-72.
PMID: 35390674
Enteroendocrine cells (EECs) are the primary sensory cells that sense the gut luminal environment and secret hormones to regulate organ function. Recent studies revealed that vagal afferent neurons are connected...
4.
Sunardi M, Ito K, Enomoto H
Dev Growth Differ
. 2021 Jul;
63(6):285-294.
PMID: 34324195
The GDNF Family Ligands (GFLs) regulate neural development and kidney organogenesis by activating the RET receptor tyrosine kinase. Many RET-dependent developmental processes involve long-distance cell-cell communications or cell polarity, which...
5.
Uesaka T, Okamoto M, Nagashimada M, Tsuda Y, Kihara M, Kiyonari H, et al.
Glia
. 2021 Jul;
69(11):2575-2590.
PMID: 34272903
Hirschsprung disease (HSCR) is characterized by congenital absence of enteric neurons in distal portions of the gut. Although recent studies identified Schwann cell precursors (SCPs) as a novel cellular source...
6.
Okamoto M, Uesaka T, Ito K, Enomoto H
eNeuro
. 2021 May;
8(3).
PMID: 33958373
Mutations of the gene encoding the tyrosine kinase causes Hirschsprung's disease (HSCR) and medullary thyroid carcinoma (MTC). Current consensus holds that HSCR and MTC are induced by inactivating and activating...
7.
Nakatani T, Iwasaki M, Yamamichi A, Yoshioka Y, Uesaka T, Bitoh Y, et al.
Dev Growth Differ
. 2020 Apr;
62(4):214-222.
PMID: 32275061
Missense mutations of the RET gene have been identified in both multiple endocrine neoplasia (MEN) type 2A/B and Hirschsprung disease (HSCR: congenital absence of the enteric nervous system, ENS). Current...
8.
Generation of conditional ALK F1174L mutant mouse models for the study of neuroblastoma pathogenesis
Ono S, Saito T, Terui K, Yoshida H, Enomoto H
Genesis
. 2019 Jun;
57(10):e23323.
PMID: 31218818
Neuroblastoma, an embryonal tumor arising from the sympathetic ganglia and adrenal medulla, is among the most intractable pediatric cancers. Although a variety of genetic changes have been identified in neuroblastoma,...
9.
Hao M, Bergner A, Newgreen D, Enomoto H, Young H
Methods Mol Biol
. 2019 Apr;
1976:97-105.
PMID: 30977068
Time-lapse imaging of gut explants from embryonic mice in which neural crest-derived cells express fluorescent proteins allows the behavior of enteric neural crest cells to be observed and analyzed. Explants...
10.
Okamoto M, Yoshioka Y, Maeda K, Bito Y, Fukumoto T, Uesaka T, et al.
Genesis
. 2019 Mar;
57(5):e23292.
PMID: 30884088
Medullary thyroid carcinoma (MTC) develops from hyperplasia of thyroid C cells and represents one of the major causes of thyroid cancer mortality. Mutations in the cysteine-rich domain (CRD) of the...