Hideaki Fujii
Overview
Explore the profile of Hideaki Fujii including associated specialties, affiliations and a list of published articles.
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Articles
125
Citations
754
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Recent Articles
1.
Itoh K, Nakahara H, Takashino A, Hara A, Katsuno A, Abe Y, et al.
RSC Med Chem
. 2024 Oct;
PMID: 39464650
[This corrects the article DOI: 10.1039/D4MD00599F.].
2.
Itoh K, Nakahara H, Takashino A, Hara A, Katsuno A, Abe Y, et al.
RSC Med Chem
. 2024 Oct;
PMID: 39399310
The incorporation of saturated nitrogen-containing heterocycle 1,2,5-oxadiazinane into small molecules represents a compelling avenue in drug discovery due to its unexplored behavior within biological systems and incomplete protocols for synthesis....
3.
Watanabe A, Yamada S, Yoshida H, Inagaki M, Atsumi N, Matsushima A, et al.
Chem Pharm Bull (Tokyo)
. 2024 Jul;
72(7):711-730.
PMID: 39085079
Although opioid analgesics are indispensable in treating pain, these drugs are accompanied by life-threatening side effects. While clinically relevant opioid drugs target the µ opioid receptor (MOR), a heterodimer between...
4.
Miyano K, Nonaka M, Sakamoto M, Murofushi M, Yoshida Y, Komura K, et al.
Int J Mol Sci
. 2024 May;
25(9).
PMID: 38732124
Oxytocin, a significant pleiotropic neuropeptide, regulates psychological stress adaptation and social communication, as well as peripheral actions, such as uterine contraction and milk ejection. Recently, a Japanese Kampo medicine called...
5.
Iwai T, Mishima R, Hirayama S, Nakajima H, Oyama M, Watanabe S, et al.
J Clin Med
. 2024 Jan;
13(2).
PMID: 38276114
The δ opioid receptor (DOR) inverse agonist has been demonstrated to improve learning and memory impairment in mice subjected to restraint stress. Here, we investigated the effects of SYK-623, a...
6.
Karaki F, Takamori T, Kawakami K, Sakurai S, Hidaka K, Ishii K, et al.
Molecules
. 2023 Oct;
28(19).
PMID: 37836768
In medicinal chemistry, the copper-catalyzed click reaction is used to prepare ligand candidates. This reaction is so clean that the bioactivities of the products can be determined without purification. Despite...
7.
Moriya Y, Kasahara Y, Shimada M, Sakakibara Y, Fujii H, Nagase H, et al.
J Pharmacol Sci
. 2023 Feb;
151(3):135-141.
PMID: 36828615
Previous pharmacological data have shown the possible existence of functional interactions between μ- (MOP), κ- (KOP), and δ-opioid receptors (DOP) in pain and mood disorders. We previously reported that MOP...
8.
Mizuguchi T, Miyano K, Yamauchi R, Yoshida Y, Takahashi H, Yamazaki A, et al.
Peptides
. 2022 Nov;
159:170901.
PMID: 36347314
Positive allosteric modulators (PAMs) of G protein-coupled receptors (GPCRs) have drawn attention as novel drug candidates. PAMs can enhance the activities of endogenous agonists which are not only secreted at...
9.
Yamaguchi M, Miyano K, Hirayama S, Karasawa Y, Ohshima K, Uezono E, et al.
Molecules
. 2022 Oct;
27(20).
PMID: 36296658
Opioid receptors (ORs) are classified into three types (μ, δ, and κ), and opioid analgesics are mainly mediated by μOR activation; however, their use is sometimes restricted by unfavorable effects....
10.
Itoh K, Odate F, Karikomi T, Obe K, Miyamori T, Kamiya H, et al.
RSC Adv
. 2022 May;
9(22):12365-12369.
PMID: 35515875
A novel asymmetric photodimerization reaction of coumarin derivatives bearing the ()-4-benzyl-2-oxazolidinone auxiliary provides only the -head-to-tail (-HT) dimer with moderate diastereoselectivity (up to 75 : 25). The mechanism of complete...