Heshani de Silva
Overview
Explore the profile of Heshani de Silva including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
7
Citations
1099
Followers
0
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Recent Articles
1.
Carril-Ajuria L, Lavaud P, Dalban C, Negrier S, Gravis G, Motzer R, et al.
Eur J Cancer
. 2024 Apr;
204:114048.
PMID: 38653033
Background: The Lung Immune Prognostic Index (LIPI) is associated with immune checkpoint inhibitors (ICI) outcomes across different solid tumors, particularly in non-small cell lung cancer. Data regarding the prognostic and/or...
2.
Abeysundara P, Nishad N, Balendran K, Pabasara M, Bandara P, Perera N, et al.
J Infect Dev Ctries
. 2020 Feb;
13(5):445-448.
PMID: 32053514
Introduction: European cultural norms have influenced physicians' attire in Sri Lanka. The necktie is one such item of clothing which is worn to be recognized and respected as professionals. This...
3.
Iorio F, Knijnenburg T, Vis D, Bignell G, Menden M, Schubert M, et al.
Cell
. 2016 Jul;
166(3):740-754.
PMID: 27397505
Systematic studies of cancer genomes have provided unprecedented insights into the molecular nature of cancer. Using this information to guide the development and application of therapies in the clinic is...
4.
Ross-Macdonald P, de Silva H, Patel V, Truong A, He A, Neuhaus I, et al.
Bioorg Med Chem
. 2011 Dec;
20(6):1961-72.
PMID: 22137930
Therapeutic development of a targeted agent involves a series of decisions over additional activities that may be ignored, eliminated or pursued. This paper details the concurrent application of two methods...
5.
Ji R, de Silva H, Jin Y, Bruccoleri R, Cao J, He A, et al.
PLoS Comput Biol
. 2009 Sep;
5(9):e1000512.
PMID: 19763178
The dose response curve is the gold standard for measuring the effect of a drug treatment, but is rarely used in genomic scale transcriptional profiling due to perceived obstacles of...
6.
Ross-Macdonald P, de Silva H, Guo Q, Xiao H, Hung C, Penhallow B, et al.
Mol Cancer Ther
. 2008 Nov;
7(11):3490-8.
PMID: 19001433
In developing inhibitors of the LIM kinases, the initial lead molecules combined potent target inhibition with potent cytotoxic activity. However, as subsequent compounds were evaluated, the cytotoxic activity separated from...
7.
Lackner M, Kindt R, Carroll P, Brown K, Cancilla M, Chen C, et al.
Cancer Cell
. 2005 Apr;
7(4):325-36.
PMID: 15837622
A chemical genetics approach identified a cellular target of several proapoptotic farnesyl transferase inhibitors (FTIs). Treatment with these FTIs caused p53-independent apoptosis in Caenorhabditis elegans, which was mimicked by knockdown...