Henry R Maun
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Explore the profile of Henry R Maun including associated specialties, affiliations and a list of published articles.
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21
Citations
599
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Recent Articles
11.
Hotzel I, Chiang V, Diao J, Pantua H, Maun H, Kapadia S
Protein Eng Des Sel
. 2011 Aug;
24(9):679-89.
PMID: 21810920
The application of phage display technology to mammalian proteins with multiple transmembrane regions has had limited success due to the difficulty in generating these proteins in sufficient amounts and purity....
12.
Landgraf K, Santell L, Billeci K, Quan C, Young J, Maun H, et al.
J Biol Chem
. 2010 Oct;
285(51):40362-72.
PMID: 20937841
Hepatocyte growth factor (HGF) binds to its target receptor tyrosine kinase, Met, as a single-chain form (pro-HGF) or as a cleaved two-chain disulfide-linked α/β-heterodimer. However, only two-chain HGF stimulates Met...
13.
Maun H, Kirchhofer D, Lazarus R
Biol Chem
. 2010 Jun;
391(8):881-92.
PMID: 20536384
Proteases represent a large class of enzymes with crucial biological functions. Although targeting various relevant proteases for therapeutic intervention has been widely investigated, structurally related proteins lacking proteolytic activity (pseudo-proteases)...
14.
Maun H, Wen X, Lingel A, de Sauvage F, Lazarus R, Scales S, et al.
J Biol Chem
. 2010 May;
285(34):26570-80.
PMID: 20504762
Proper hedgehog (Hh) signaling is crucial for embryogenesis and tissue regeneration. Dysregulation of this pathway is associated with several types of cancer. The monoclonal antibody 5E1 is a Hh pathway...
15.
Kachalova G, Bourenkov G, Mengesdorf T, Schenk S, Maun H, Burghammer M, et al.
J Mol Biol
. 2009 Dec;
396(3):785-99.
PMID: 20006620
The pathway for oxidative degradation of nicotine in Arthrobacter nicotinovorans includes two genetically and structurally unrelated flavoenzymes, 6-hydroxy-L-nicotine oxidase (6HLNO) and 6-hydroxy-D-nicotine oxidase, which act with absolute stereospecificity on the...
16.
Bosanac I, Maun H, Scales S, Wen X, Lingel A, Bazan J, et al.
Nat Struct Mol Biol
. 2009 Jun;
16(7):691-7.
PMID: 19561609
Hedgehog (Hh) signaling is crucial for many aspects of embryonic development, whereas dysregulation of this pathway is associated with several types of cancer. Hedgehog-interacting protein (Hhip) is a surface receptor...
17.
Kirchhofer D, Lipari M, Santell L, Billeci K, Maun H, Sandoval W, et al.
Proc Natl Acad Sci U S A
. 2007 Mar;
104(13):5306-11.
PMID: 17372204
Hepatocyte growth factor (HGF), the ligand for the receptor tyrosine kinase Met, is secreted as single chain pro-HGF that lacks signaling activity. Pro-HGF acquires functional competence upon cleavage between R494...
18.
Maun H, Eigenbrot C, Raab H, Arnott D, Phu L, Bullens S, et al.
Protein Sci
. 2005 Apr;
14(5):1171-80.
PMID: 15840825
Proteolytic processing of zymogen Factor VII to Factor VIIa (FVIIa) is necessary but not sufficient for maximal proteolytic activity, which requires an additional allosteric influence induced upon binding to its...
19.
Merchant M, Vajdos F, Ultsch M, Maun H, Wendt U, Cannon J, et al.
Mol Cell Biol
. 2004 Sep;
24(19):8627-41.
PMID: 15367681
The Hedgehog pathway drives proliferation and differentiation by activating the Gli/Ci family of zinc finger transcription factors. Gli/Ci proteins form Hedgehog signaling complexes with other signaling components, including the kinesin-like...
20.
Kirchhofer D, Yao X, Peek M, Eigenbrot C, Lipari M, Billeci K, et al.
J Biol Chem
. 2004 Jun;
279(38):39915-24.
PMID: 15218027
Hepatocyte growth factor (HGF), a plasminogen-related growth factor, is the ligand for Met, a receptor tyrosine kinase implicated in development, tissue regeneration, and invasive tumor growth. HGF acquires signaling activity...