Henry I Yamamura
Overview
Explore the profile of Henry I Yamamura including associated specialties, affiliations and a list of published articles.
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Articles
39
Citations
578
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Recent Articles
1.
Yamamoto T, Nair P, Largent-Milnes T, Jacobsen N, Davis P, Ma S, et al.
J Med Chem
. 2011 Mar;
54(7):2029-38.
PMID: 21366266
Multivalent ligands with δ/μ opioid agonist and NK1 antagonist activities have shown promising analgesic potency without detectable sign of toxicities, including motor skill impairment and opioid-induced tolerance. To improve their...
2.
Yamamoto T, Nair P, Jacobsen N, Kulkarni V, Davis P, Ma S, et al.
J Med Chem
. 2010 Jul;
53(15):5491-501.
PMID: 20617791
Neuropathic pain states and tolerance to opioids can result from system changes in the CNS, such as up-regulation of the NK1 receptor and substance P, lead to antiopioid effects in...
3.
Yamamoto T, Nair P, Jacobsen N, Vagner J, Kulkarni V, Davis P, et al.
J Med Chem
. 2010 Jun;
52(16):5164-75.
PMID: 20560643
In order to obtain a metabolically more stable analgesic peptide derivative, O-beta-glycosylated serine (Ser(Glc)) was introduced into TY027 (Tyr-d-Ala-Gly-Phe-Met-Pro-Leu-Trp-NH-3',5'-Bzl(CF(3))(2)) which was a previously reported bifunctional compound with delta/micro opioid agonist...
4.
Yamamoto T, Nair P, Ma S, Davis P, Yamamura H, Vanderah T, et al.
Bioorg Med Chem
. 2009 Sep;
17(20):7337-43.
PMID: 19762245
In order to improve metabolic stability, a ring structure with a cystine moiety was introduced into TY027 (Tyr-D-Ala-Gly-Phe-Met-Pro-Leu-Trp-NH-[3',5'-(CF(3))(2)Bzl]), which is a lead compound of our developing bifunctional peptide possessing opioid...
5.
Tumati S, Yamamura H, Vanderah T, Roeske W, Varga E
J Pharmacol Exp Ther
. 2009 Jun;
330(3):810-7.
PMID: 19491327
Studies have shown that long-term (5alpha,6alpha)-7,8-didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol (morphine) treatment increases the sensitivity to painful heat stimuli (thermal hyperalgesia). The cellular adaptations contributing to sustained morphine-mediated pain sensitization are not fully understood....
6.
Nair P, Yamamoto T, Kulkarni V, Moye S, Navratilova E, Davis P, et al.
Adv Exp Med Biol
. 2009 Apr;
611:537-8.
PMID: 19400302
No abstract available.
7.
Tumati S, Yamamura H, St John P, Vanderah T, Roeske W, Varga E
Neuroreport
. 2009 Apr;
20(8):815-9.
PMID: 19387418
Studies have shown that sustained cannabinoid treatment increases the sensitivity to painful heat stimuli (thermal hyperalgesia) and innocuous mechanical stimuli (tactile allodynia). It has been suggested that augmented release of...
8.
Fioravanti B, De Felice M, Stucky C, Medler K, Luo M, Gardell L, et al.
J Neurosci
. 2008 Nov;
28(45):11593-602.
PMID: 18987195
The potential modulation of TRPV1 nociceptive activity by the CB(1) receptor was investigated here using CB(1) wild-type (WT) and knock-out (KO) mice as well as selective CB(1) inverse agonists. No...
9.
Tumati S, Milnes T, Yamamura H, Vanderah T, Roeske W, Varga E
Eur J Pharmacol
. 2008 Nov;
601(1-3):207-8.
PMID: 18976650
Studies have demonstrated that long-term opioid treatment leads to an increased sensitivity to painful (hyperalgesia) or normally innocuous (allodynia) stimuli. The molecular mechanisms that lead to paradoxical pain sensitization upon...
10.
Yamamoto T, Nair P, Jacobsen N, Davis P, Ma S, Navratilova E, et al.
J Med Chem
. 2008 Sep;
51(20):6334-47.
PMID: 18821747
To provide new insight into the determining factors of membrane-bound peptide conformation that might play an important role in peptide-receptor docking and further biological behaviors, the dodecylphosphocholine (DPC) micelle-bound conformations...