Henry I Yamamura
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Explore the profile of Henry I Yamamura including associated specialties, affiliations and a list of published articles.
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39
Citations
578
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Recent Articles
11.
Yue X, Tumati S, Navratilova E, Strop D, St John P, Vanderah T, et al.
Eur J Pharmacol
. 2008 Mar;
584(2-3):272-7.
PMID: 18328477
Recent studies suggest that sustained morphine-mediated paradoxical pain may play an important role in the development of analgesic tolerance. The intracellular signal transduction pathways involved in sustained opioid mediated augmentation...
12.
Yamamoto T, Nair P, Vagner J, Largent-Milnes T, Davis P, Ma S, et al.
J Med Chem
. 2008 Feb;
51(5):1369-76.
PMID: 18266313
A series of bifunctional peptides with opioid agonist and substance P antagonist bioactivities were designed with the concept of overlapping pharmacophores. In this concept, the bifunctional peptides were expected to...
13.
Georgieva T, Devanathan S, Stropova D, Park C, Salamon Z, Tollin G, et al.
Eur J Pharmacol
. 2007 Dec;
581(1-2):19-29.
PMID: 18162180
Cannabinoid drugs differ in their rank order of potency to produce analgesia versus other central nervous system effects. We propose that these differences are due to unique agonist-bound cannabinoid CB1...
14.
Yamamoto T, Nair P, Davis P, Ma S, Navratilova E, Moye S, et al.
J Med Chem
. 2007 May;
50(12):2779-86.
PMID: 17516639
A series of bifunctional peptides that act as agonists for delta and mu opioid receptors with delta selectivity and as antagonist for neurokinin-1 (NK1) receptors were designed and synthesized for...
15.
Nissan H, Lu J, Booth N, Yamamura H, Farnsworth N, Wang Z
J Ethnopharmacol
. 2007 Mar;
112(1):207-10.
PMID: 17350196
Trifolium pratense (TP) is one of the most common herbs for the relief of menopausal symptoms. Little is known about its mechanisms of action. In this study, we investigated the...
16.
Navratilova E, Waite S, Stropova D, Eaton M, Alves I, Hruby V, et al.
Mol Pharmacol
. 2007 Feb;
71(5):1416-26.
PMID: 17322005
Agonist-mediated desensitization of the opioid receptors is thought to function as a protective mechanism against sustained opioid signaling and therefore may prevent the development of opioid tolerance. However, the exact...
17.
Cai M, Varga E, Stankova M, Mayorov A, Perry J, Yamamura H, et al.
Chem Biol Drug Des
. 2006 Nov;
68(4):183-93.
PMID: 17105482
Melanocortin hormones and neurotransmitters regulate a vast array of physiologic processes by interacting with five G-protein-coupled melanocortin receptor types. In the present study, we have systematically studied the regulation of...
18.
Hruby V, Porreca F, Yamamura H, Tollin G, Agnes R, Lee Y, et al.
AAPS J
. 2006 Oct;
8(3):E450-60.
PMID: 17025262
New modalities providing safe and effective treatment of pain, especially prolonged pathological pain, have not appeared despite much effort. In this mini-review/overview we suggest that new paradigms of drug design...
19.
Yue X, Varga E, Stropova D, Vanderah T, Yamamura H, Roeske W
Eur J Pharmacol
. 2006 Jun;
540(1-3):57-9.
PMID: 16750187
The utility of morphine for the treatment of chronic pain is limited by the development of analgesic tolerance. Adenylyl cyclase (AC) superactivation, induced by chronic opioid agonist administration, is regarded...
20.
Oki T, Maruyama S, Takagi Y, Yamamura H, Yamada S
Eur J Pharmacol
. 2005 Dec;
529(1-3):157-63.
PMID: 16316647
The current study was undertaken to characterize the effects of oral administration of tolterodine on muscarinic receptor binding in the bladder and submaxillary gland and on salivation in mice. In...