Henning Tidow
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Explore the profile of Henning Tidow including associated specialties, affiliations and a list of published articles.
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55
Citations
1356
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Recent Articles
11.
Kehlenbeck D, Traore D, Josts I, Sander S, Moulin M, Haertlein M, et al.
FEBS J
. 2021 Dec;
289(10):2959-2970.
PMID: 34921499
The ATP-binding cassette transporter MsbA is a lipid flippase, translocating lipid A, glycolipids, and lipopolysaccharides from the inner to the outer leaflet of the inner membrane of Gram-negative bacteria. It...
12.
Kryshtafovych A, Moult J, Albrecht R, Chang G, Chao K, Fraser A, et al.
Proteins
. 2021 Aug;
89(12):1633-1646.
PMID: 34449113
Critical assessment of structure prediction (CASP) conducts community experiments to determine the state of the art in computing protein structure from amino acid sequence. The process relies on the experimental...
13.
Josts I, Veith K, Normant V, Schalk I, Tidow H
Proc Natl Acad Sci U S A
. 2021 Aug;
118(34).
PMID: 34417315
Gram-negative bacteria take up the essential ion Fe as ferric-siderophore complexes through their outer membrane using TonB-dependent transporters. However, the subsequent route through the inner membrane differs across many bacterial...
14.
Gattkowski E, Rutherford T, Mockl F, Bauche A, Sander S, Fliegert R, et al.
FEBS J
. 2021 Jun;
288(23):6769-6782.
PMID: 34189846
Nudix hydrolase 9 (NUDT9) is a member of the nucleoside linked to another moiety X (NUDIX) protein superfamily, which hydrolyses a broad spectrum of organic pyrophosphates from metabolic processes. ADP-ribose...
15.
Niebling S, Burastero O, Burgi J, Gunther C, Defelipe L, Sander S, et al.
Sci Rep
. 2021 May;
11(1):9572.
PMID: 33953265
Differential scanning fluorimetry (DSF) using the inherent fluorescence of proteins (nDSF) is a popular technique to evaluate thermal protein stability in different conditions (e.g. buffer, pH). In many cases, ligand...
16.
Gunther S, Reinke P, Fernandez-Garcia Y, Lieske J, Lane T, Ginn H, et al.
Science
. 2021 Apr;
372(6542):642-646.
PMID: 33811162
The coronavirus disease (COVID-19) caused by SARS-CoV-2 is creating tremendous human suffering. To date, no effective drug is available to directly treat the disease. In a search for a drug...
17.
Normant V, Josts I, Kuhn L, Perraud Q, Fritsch S, Hammann P, et al.
ACS Chem Biol
. 2020 Sep;
15(10):2741-2751.
PMID: 32902248
Iron is a key nutrient for almost all living organisms. Paradoxically, it is poorly soluble and consequently poorly bioavailable. Bacteria have thus developed multiple strategies to access this metal. One...
18.
Josts I, Gao Y, Monteiro D, Niebling S, Nitsche J, Veith K, et al.
Structure
. 2020 Jan;
28(3):348-354.e3.
PMID: 31899087
Recent structures of full-length ATP-binding cassette (ABC) transporter MsbA in different states indicate large conformational changes during the reaction cycle that involve transient dimerization of its nucleotide-binding domains (NBDs). However,...
19.
Danyukova T, Ludwig N, Velho R, Harms F, Gunes N, Tidow H, et al.
Hum Mutat
. 2019 Oct;
41(1):133-139.
PMID: 31579991
Mucolipidosis (ML) II and III alpha/beta are inherited lysosomal storage disorders caused by mutations in GNPTAB encoding the α/β-precursor of GlcNAc-1-phosphotransferase. This enzyme catalyzes the initial step in the modification...
20.
Almeida-Hernandez Y, Tidow H
J Phys Chem B
. 2019 Sep;
123(37):7852-7858.
PMID: 31480836
The GlpG rhomboid protease from is a well-characterized intramembrane protease that cleaves transmembrane substrates inside the lipid bilayer. Most studies have focused on the GlpG transmembrane domain containing the catalytic...