Julius Nitsche
Overview
Explore the profile of Julius Nitsche including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
63
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0
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Recent Articles
1.
Meyer C, Garzia A, Miller M, Huggins D, Myers R, Hoffmann H, et al.
Nature
. 2024 Dec;
637(8048):1178-1185.
PMID: 39663451
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The rapid development of highly effective vaccines against SARS-CoV-2 has altered the trajectory of the pandemic,...
2.
Dedden D, Nitsche J, Schneider E, Thomsen M, Schwarz D, Leuthner B, et al.
J Mol Biol
. 2024 Feb;
436(6):168483.
PMID: 38331211
RAF protein kinases are essential effectors in the MAPK pathway and are important cancer drug targets. Structural understanding of RAF activation is so far based on cryo-electron microscopy (cryo-EM) and...
3.
Josts I, Kehlenbeck D, Nitsche J, Tidow H
Methods Enzymol
. 2022 Nov;
677:417-432.
PMID: 36410958
Structural studies of integral membrane proteins (IMPs) are challenging as many of them require a lipid environment for full activity and stability. Reconstitution of IMPs into carrier systems such as...
4.
Josts I, Gao Y, Monteiro D, Niebling S, Nitsche J, Veith K, et al.
Structure
. 2020 Jan;
28(3):348-354.e3.
PMID: 31899087
Recent structures of full-length ATP-binding cassette (ABC) transporter MsbA in different states indicate large conformational changes during the reaction cycle that involve transient dimerization of its nucleotide-binding domains (NBDs). However,...
5.
Kehlenbeck D, Josts I, Nitsche J, Busch S, Forsyth V, Tidow H
Biol Chem
. 2019 May;
400(11):1509-1518.
PMID: 31141477
Membrane protein research suffers from the drawback that detergents, which are commonly used to solubilize integral membrane proteins (IMPs), often lead to protein instability and reduced activity. Recently, lipid nanodiscs...
6.
Nitsche J, Josts I, Heidemann J, Mertens H, Maric S, Moulin M, et al.
Commun Biol
. 2018 Dec;
1:206.
PMID: 30511020
Plasma-membrane Ca-ATPases expel Ca from the cytoplasm and are key regulators of Ca homeostasis in eukaryotes. They are autoinhibited under low Ca concentrations. Calmodulin (CaM)-binding to a unique regulatory domain...
7.
Josts I, Nitsche J, Maric S, Mertens H, Moulin M, Haertlein M, et al.
Structure
. 2018 Jun;
26(8):1072-1079.e4.
PMID: 29937358
Structural studies of integral membrane proteins (IMPs) are challenging, as many of them are inactive or insoluble in the absence of a lipid environment. Here, we describe an approach making...
8.
Veith K, Martinez Molledo M, Almeida Hernandez Y, Josts I, Nitsche J, Low C, et al.
Chembiochem
. 2017 Jun;
18(17):1735-1742.
PMID: 28603929
A crucial bottleneck in membrane protein structural biology is the difficulty in identifying a detergent that can maintain the stability and functionality of integral membrane proteins (IMPs). Detergents are poor...