Henk W P van den Toorn
Overview
Explore the profile of Henk W P van den Toorn including associated specialties, affiliations and a list of published articles.
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17
Citations
382
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Recent Articles
1.
Dingess K, Gazi I, van den Toorn H, Mank M, Stahl B, Reiding K, et al.
Int J Mol Sci
. 2021 Aug;
22(15).
PMID: 34360914
Human milk is a vital biofluid containing a myriad of molecular components to ensure an infant's best start at a healthy life. One key component of human milk is β-casein,...
2.
Prust N, van der Laarse S, van den Toorn H, Van Sorge N, Lemeer S
Mol Cell Proteomics
. 2021 Jan;
20:100034.
PMID: 33444734
Staphylococcus aureus is a major cause of infections worldwide, and infection results in a variety of diseases. As of no surprise, protein phosphorylation is an important game player in signaling...
3.
Demmers L, Kretzschmar K, Van Hoeck A, Bar-Epraim Y, van den Toorn H, Koomen M, et al.
Nat Commun
. 2020 Oct;
11(1):5338.
PMID: 33087703
Tumor heterogeneity is a major cause of therapeutic resistance. Immunotherapy may exploit alternative vulnerabilities of drug-resistant cells, where tumor-specific human leukocyte antigen (HLA) peptide ligands are promising leads to invoke...
4.
Steigenberger B, van den Toorn H, Bijl E, Greisch J, Rather O, Lubeck M, et al.
Mol Cell Proteomics
. 2020 Jul;
19(10):1677-1687.
PMID: 32694122
Ion mobility separates molecules in the gas-phase based on their physico-chemical properties, providing information about their size as collisional cross-sections. The timsTOF Pro combines trapped ion mobility with a quadrupole,...
5.
Potel C, Lin M, Prust N, van den Toorn H, Heck A, Lemeer S
Anal Chem
. 2019 Apr;
91(9):5542-5547.
PMID: 30969750
Recent technological advances have made it possible to investigate the hitherto rather elusive protein histidine phosphorylation. However, confident site-specific localization of protein histidine phosphorylation remains challenging. Here, we address this...
6.
Dingess K, van den Toorn H, Mank M, Stahl B, Heck A
Anal Bioanal Chem
. 2019 Feb;
411(7):1351-1363.
PMID: 30710207
There is a growing interest for investigating endogenous peptides from human biofluids which may provide yet unknown functional benefits or provide an early indication of disease states as potential biomarkers....
7.
Cristobal A, Marino F, Post H, van den Toorn H, Mohammed S, Heck A
Anal Chem
. 2017 Feb;
89(6):3318-3325.
PMID: 28233997
Mass spectrometry (MS)-based proteomics workflows can crudely be classified into two distinct regimes, targeting either relatively small peptides (i.e., 0.7 kDa < M < 3.0 kDa) or small to medium...
8.
Cristobal A, van den Toorn H, van de Wetering M, Clevers H, Heck A, Mohammed S
Cell Rep
. 2017 Jan;
18(1):263-274.
PMID: 28052255
Diseases at the molecular level are complex and patient dependent, necessitating development of strategies that enable precision treatment to optimize clinical outcomes. Organoid technology has recently been shown to have...
9.
Selvan N, Mariappa D, van den Toorn H, Heck A, Ferenbach A, van Aalten D
J Biol Chem
. 2015 Mar;
290(19):11969-82.
PMID: 25778404
Protein O-GlcNAcylation is a reversible post-translational signaling modification of nucleocytoplasmic proteins that is essential for embryonic development in bilateria. In a search for a reductionist model to study O-GlcNAc signaling,...
10.
Walzer M, Pernas L, Nasso S, Bittremieux W, Nahnsen S, Kelchtermans P, et al.
Mol Cell Proteomics
. 2014 Apr;
13(8):1905-13.
PMID: 24760958
Quality control is increasingly recognized as a crucial aspect of mass spectrometry based proteomics. Several recent papers discuss relevant parameters for quality control and present applications to extract these from...