Richard A Scheltema
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Explore the profile of Richard A Scheltema including associated specialties, affiliations and a list of published articles.
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57
Citations
4562
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Recent Articles
1.
Siehler J, Bilekova S, Chapouton P, Dema A, Albanese P, Tamara S, et al.
Nat Metab
. 2024 Nov;
6(12):2374-2390.
PMID: 39587340
Blunted first-phase insulin secretion and insulin deficiency are indicators of β cell dysfunction and diabetes manifestation. Therefore, insights into molecular mechanisms that regulate insulin homeostasis might provide entry sites to...
2.
Heissel S, He Y, Jankevics A, Shi Y, Molina H, Viner R, et al.
Mol Cell Proteomics
. 2024 Apr;
23(5):100759.
PMID: 38574859
Recombinant expression of proteins, propelled by therapeutic antibodies, has evolved into a multibillion dollar industry. Essential here is the quality control assessment of critical attributes, such as sequence fidelity, proper...
3.
Steens J, Bravo J, Salazar C, Yildiz C, Amieiro A, Kostlbacher S, et al.
Science
. 2024 Feb;
383(6682):512-519.
PMID: 38301007
The generation of cyclic oligoadenylates and subsequent allosteric activation of proteins that carry sensory domains is a distinctive feature of type III CRISPR-Cas systems. In this work, we characterize a...
4.
Bar Barroeta A, Albanese P, Kadava T, Jankevics A, Marquart J, Meijers J, et al.
J Thromb Haemost
. 2024 Jan;
22(5):1336-1346.
PMID: 38242207
Background: Factor (F)XI can be activated by proteases, including thrombin and FXIIa. The interactions of these enzymes with FXI are transient in nature and therefore difficult to study. Objectives: To...
5.
Mirzakhanyan Y, Jankevics A, Scheltema R, Gershon P
mBio
. 2023 Aug;
14(5):e0113523.
PMID: 37646531
An outstanding problem in the understanding of poxvirus biology is the molecular structure of the mature virion. Via deep learning methods combined with chemical cross-linking mass spectrometry, we have addressed...
6.
Rouillon C, Eckhardt B, Kollenstart L, Gruss F, Verkennis A, Rondeel I, et al.
Nucleic Acids Res
. 2023 Mar;
51(8):3770-3792.
PMID: 36942484
During every cell cycle, both the genome and the associated chromatin must be accurately replicated. Chromatin Assembly Factor-1 (CAF-1) is a key regulator of chromatin replication, but how CAF-1 functions...
7.
Hevler J, Albanese P, Cabrera-Orefice A, Potter A, Jankevics A, Misic J, et al.
Open Biol
. 2023 Feb;
13(3):220363.
PMID: 36854377
The tricarboxylic acid cycle is the central pathway of energy production in eukaryotic cells and plays a key part in aerobic respiration throughout all kingdoms of life. One of the...
8.
Nieuwkoop T, Terlouw B, Stevens K, Scheltema R, de Ridder D, van der Oost J, et al.
Nucleic Acids Res
. 2023 Jan;
51(5):2363-2376.
PMID: 36718935
It has been known for decades that codon usage contributes to translation efficiency and hence to protein production levels. However, its role in protein synthesis is still only partly understood....
9.
Gemmer M, Chaillet M, van Loenhout J, Cuevas Arenas R, Vismpas D, Grollers-Mulderij M, et al.
Nature
. 2023 Jan;
614(7946):160-167.
PMID: 36697828
The dynamic ribosome-translocon complex, which resides at the endoplasmic reticulum (ER) membrane, produces a major fraction of the human proteome. It governs the synthesis, translocation, membrane insertion, N-glycosylation, folding and...
10.
Burke D, Bryant P, Barrio-Hernandez I, Memon D, Pozzati G, Shenoy A, et al.
Nat Struct Mol Biol
. 2023 Jan;
30(2):216-225.
PMID: 36690744
Cellular functions are governed by molecular machines that assemble through protein-protein interactions. Their atomic details are critical to studying their molecular mechanisms. However, fewer than 5% of hundreds of thousands...