Helena Ostolaza
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Explore the profile of Helena Ostolaza including associated specialties, affiliations and a list of published articles.
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37
Citations
1259
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Recent Articles
1.
Ostolaza H, Amuategi J
Int J Mol Sci
. 2024 Mar;
25(6).
PMID: 38542105
RTX toxins are important virulence factors produced by a wide range of Gram-negative bacteria. They are secreted as water-soluble proteins that are able to bind to the host cell membrane...
2.
Amuategi J, Alonso R, Ostolaza H
Int J Mol Sci
. 2022 Aug;
23(15).
PMID: 35955837
Adenylate Cyclase Toxin (ACT or CyaA) is one of the important virulence factors secreted by , the bacterium causative of whooping cough. ACT debilitates host defenses by production of unregulated...
3.
Jebari-Benslaiman S, Uribe K, Benito-Vicente A, Galicia-Garcia U, Larrea-Sebal A, Santin I, et al.
Small
. 2022 Feb;
18(13):e2105915.
PMID: 35156292
Cardiovascular disease, the leading cause of mortality worldwide, is primarily caused by atherosclerosis, which is characterized by lipid and inflammatory cell accumulation in blood vessels and carotid intima thickening. Although...
4.
Larrea-Sebal A, Benito-Vicente A, Fernandez-Higuero J, Jebari-Benslaiman S, Galicia-Garcia U, Uribe K, et al.
JACC Basic Transl Sci
. 2021 Dec;
6(11):815-827.
PMID: 34869944
Untreated familial hypercholesterolemia (FH) leads to atherosclerosis and early cardiovascular disease. Mutations in the low-density lipoprotein receptor () gene constitute the major cause of FH, and the high number of...
5.
Gonzalez Bullon D, Uribe K, Amuategi J, Martin C, Ostolaza H
FEBS J
. 2021 Jul;
288(23):6795-6814.
PMID: 34216517
Several toxins acting on animal cells present different, but specific, interactions with cholesterol. Bordetella pertussis infects the human respiratory tract and causes whooping cough, a highly contagious and resurgent disease....
6.
Jebari-Benslaiman S, Uribe K, Benito-Vicente A, Galicia-Garcia U, Larrea-Sebal A, Alloza I, et al.
Biomedicines
. 2020 Sep;
8(10).
PMID: 32977626
Methods: the cholesterol efflux activity of soybean PC (Soy-PC), 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), DPPC:Chol:1-palmitoyl-2-hydroxy-sn-glycero-3-phosphocholine (LysoPC) and DPPC:18:2 cholesteryl ester (CE):LysoPC rHDLs was determined in several cell models to investigate the contribution of...
7.
Galicia-Garcia U, Benito-Vicente A, Jebari S, Larrea-Sebal A, Siddiqi H, Uribe K, et al.
Int J Mol Sci
. 2020 Sep;
21(17).
PMID: 32872570
Type 2 Diabetes Mellitus (T2DM), one of the most common metabolic disorders, is caused by a combination of two primary factors: defective insulin secretion by pancreatic β-cells and the inability...
8.
Galicia-Garcia U, Jebari S, Larrea-Sebal A, Uribe K, Siddiqi H, Ostolaza H, et al.
Int J Mol Sci
. 2020 Jul;
21(13).
PMID: 32630698
Statins are the gold-standard treatment for the prevention of primary and secondary cardiovascular disease, which is the leading cause of mortality worldwide. Despite the safety and relative tolerability of statins,...
9.
Galicia-Garcia U, Benito-Vicente A, Uribe K, Jebari S, Larrea-Sebal A, Alonso-Estrada R, et al.
Sci Rep
. 2020 Feb;
10(1):1727.
PMID: 32015373
The primary genetic cause of familial hypercholesterolemia (FH) is related to mutations in the LDLR gene encoding the Low-density Lipoprotein Receptor. LDLR structure is organized in 5 different domains, including...
10.
Etxaniz A, Gonzalez-Bullon D, Martin C, Alonso M, Ostolaza H
FEBS J
. 2019 Oct;
287(9):1798-1815.
PMID: 31652486
Rapid plasma membrane repair in response to pore-forming toxins is crucial for cell survival, but the molecular mechanisms employed by eukaryotic nucleated cells to maintain membrane integrity and the specificities...