Felix M Goni
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Explore the profile of Felix M Goni including associated specialties, affiliations and a list of published articles.
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194
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4529
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Recent Articles
1.
Ahyayauch H, Masserini M, Alonso A, Goni F
Int J Mol Sci
. 2024 Jun;
25(12).
PMID: 38928107
Aβ peptides are known to bind neural plasma membranes in a process leading to the deposit of Aβ-enriched plaques. These extracellular structures are characteristic of Alzheimer's disease, the major cause...
2.
Ahyayauch H, Masserini M, Goni F, Alonso A
Biomolecules
. 2024 Mar;
14(3).
PMID: 38540718
The amyloidogenic Aβ peptides are widely considered as a pathogenic agent in Alzheimer's disease. Aβ(1-42) would form aggregates of amyloid fibrils on the neuron plasma membranes, thus perturbing neuronal functionality....
3.
Font-Mateu J, Sanllehi P, Sot J, Abad B, Mateos N, Torreno-Pina J, et al.
Cell Mol Life Sci
. 2024 Feb;
81(1):98.
PMID: 38386110
In hormone-responsive breast cancer cells, progesterone (P4) has been shown to act via its nuclear receptor (nPR), a ligand-activated transcription factor. A small fraction of progesterone receptor is palmitoylated and...
4.
Ballesteros U, Iriondo M, Varela Y, Goni F, Alonso A, Montes L, et al.
Int J Biol Macromol
. 2024 Feb;
262(Pt 1):129835.
PMID: 38302024
Autophagy is a catabolic process in which a double-membrane organelle, the autophagosome (AP), engulfs cellular components that will be degraded in the lysosomes. ATG8 protein family members participate at various...
5.
Ballesteros U, Gonzalez-Ramirez E, de la Arada I, Sot J, Etxaniz A, Goni F, et al.
Int J Mol Sci
. 2023 Dec;
24(23).
PMID: 38068893
-maleimide-derivatized phospholipids are often used to facilitate protein anchoring to membranes. In autophagy studies, this is applied to the covalent binding of Atg8, an autophagy protein, to a phosphatidylethanolamine (PE)...
6.
Varela Y, Iriondo M, Goni F, Alonso A, Montes L
Biochim Biophys Acta Mol Cell Biol Lipids
. 2023 Dec;
1869(2):159444.
PMID: 38056762
Specific membrane lipids play unique roles in (macro)autophagy. Those include phosphatidylethanolamine, to which LC3/GABARAP autophagy proteins become covalently bound in the process, or cardiolipin, an important effector in mitochondrial autophagy...
7.
Varela Y, Gonzalez-Ramirez E, Iriondo M, Ballesteros U, Etxaniz A, Montes L, et al.
Int J Mol Sci
. 2023 Mar;
24(6).
PMID: 36982156
Cardiolipin (CL) is a key lipid for damaged mitochondrial recognition by the LC3/GABARAP human autophagy proteins. The role of ceramide (Cer) in this process is unclear, but CL and Cer...
8.
Iriondo M, Etxaniz A, Varela Y, Ballesteros U, Lazaro M, Valle M, et al.
Cell Mol Life Sci
. 2023 Feb;
80(2):56.
PMID: 36729310
In macroautophagy, the autophagosome (AP) engulfs portions of cytoplasm to allow their lysosomal degradation. AP formation in humans requires the concerted action of the ATG12 and LC3/GABARAP conjugation systems. The...
9.
Gomez-Fernandez J, Goni F
Biomedicines
. 2022 Nov;
10(11).
PMID: 36359192
In the early 1970s, the existence of a "lipid annulus" stably surrounding the individual intrinsic protein molecules was proposed by several authors. They referred to a number of lipid molecules...
10.
Goni F
Biochem Biophys Res Commun
. 2022 Nov;
633:23-25.
PMID: 36344153
Sphingomyelin has been considered as a merely structural lipid for many years. However, this organelle-specific lipid has many other roles, including increasing membrane molecular order, acting as a source of...