Helena Jernberg-Wiklund
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Explore the profile of Helena Jernberg-Wiklund including associated specialties, affiliations and a list of published articles.
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31
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749
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Recent Articles
11.
Agarwal P, Alzrigat M, Parraga A, Enroth S, Singh U, Ungerstedt J, et al.
Oncotarget
. 2016 Jan;
7(6):6809-23.
PMID: 26755663
Multiple myeloma (MM) is a malignancy of the antibody-producing plasma cells. MM is a highly heterogeneous disease, which has hampered the identification of a common underlying mechanism for disease establishment...
12.
Mansouri L, Sutton L, Ljungstrom V, Bondza S, Arngarden L, Bhoi S, et al.
J Exp Med
. 2015 May;
212(6):833-43.
PMID: 25987724
NF-κB is constitutively activated in chronic lymphocytic leukemia (CLL); however, the implicated molecular mechanisms remain largely unknown. Thus, we performed targeted deep sequencing of 18 core complex genes within the...
13.
The IGF-1 receptor inhibitor picropodophyllin potentiates the anti-myeloma activity of a BH3-mimetic
Bieghs L, Lub S, Fostier K, Maes K, Van Valckenborgh E, Menu E, et al.
Oncotarget
. 2014 Jul;
5(22):11193-208.
PMID: 25008202
The ABT-analogous 737, 263 and 199 are BH3 mimetics showing potent anti-myeloma (MM) activity, but only on defined molecular subgroups of MM patients presenting a Bcl-2high/Mcl-1low profile. IGF-1 is a...
14.
Kharaziha P, De Raeve H, Fristedt C, Li Q, Gruber A, Johnsson P, et al.
Cancer Res
. 2012 Sep;
72(20):5348-62.
PMID: 22952216
Multiple myeloma (MM) is a B-cell malignancy characterized by the expansion of clonal plasma blasts/plasma cells within the bone marrow that relies on multiple signaling cascades, including tyrosine kinase activated...
15.
Lemaire M, Fristedt C, Agarwal P, Menu E, Van Valckenborgh E, de Bruyne E, et al.
Clin Cancer Res
. 2012 Mar;
18(8):2230-9.
PMID: 22392915
Purpose: We have previously shown the use of the insulin-like growth factor type 1 receptor tyrosine kinase (IGF-1RTK) inhibitor picropodophyllin (PPP) as an attractive strategy to combat multiple myeloma (MM)...
16.
Halldorsdottir A, Kanduri M, Marincevic M, Mansouri L, Isaksson A, Goransson H, et al.
Am J Hematol
. 2012 Mar;
87(4):361-7.
PMID: 22374828
Mantle cell lymphoma (MCL) and chronic lymphocytic leukemia (CLL) are mature CD5(+) B-cell malignancies with different biological/clinical characteristics. We recently reported an association between different prognostic subgroups of CLL (i.e.,...
17.
Jernberg-Wiklund H, Nilsson K
Ups J Med Sci
. 2012 Feb;
117(2):166-77.
PMID: 22348393
Multiple myeloma (MM) is a B cell malignancy characterized by the expansion of clonal plasmablast/plasma cells within the bone-marrow. It is well established that the bone-marrow microenvironment has a pivotal...
18.
Hashemi J, Worrall C, Vasilcanu D, Fryknas M, Sulaiman L, Karimi M, et al.
PLoS One
. 2011 Mar;
6(3):e14757.
PMID: 21423728
Background: Picropodophyllin (PPP) is a promising novel anti-neoplastic agent that efficiently kills tumor cells in vitro and causes tumor regression and increased survival in vivo. We have previously reported that...
19.
Deng H, Lin Y, Badin M, Vasilcanu D, Stromberg T, Jernberg-Wiklund H, et al.
Biochem Biophys Res Commun
. 2010 Dec;
404(2):667-71.
PMID: 21147068
The insulin-like growth factor 1 receptor (IGF-1R) plays crucial roles in tumor cell growth and is overexpressed in many cancers. IGF-1R's trans-membrane kinase signaling pathways have been well characterized. Very...
20.
Kalushkova A, Fryknas M, Lemaire M, Fristedt C, Agarwal P, Eriksson M, et al.
PLoS One
. 2010 Jul;
5(7):e11483.
PMID: 20634887
Multiple myeloma (MM) is a genetically heterogeneous disease, which to date remains fatal. Finding a common mechanism for initiation and progression of MM continues to be challenging. By means of...