Mohammad Alzrigat
Overview
Explore the profile of Mohammad Alzrigat including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
244
Followers
0
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Recent Articles
1.
Mushtaq M, Liano-Pons J, Wang J, Alzrigat M, Yuan Y, Ruiz-Perez M, et al.
Cell Death Dis
. 2024 Nov;
15(11):836.
PMID: 39550391
Synovial sarcoma (SS) is driven by a unique t(18;X) chromosomal translocation resulting in expression of the SS18-SSX fusion oncoprotein, a transcriptional regulator with both activating and repressing functions. However, the...
2.
Yuan Y, Alzrigat M, Rodriguez-Garcia A, Wang X, Sjoberg Bexelius T, Johnsen J, et al.
Cancers (Basel)
. 2023 Sep;
15(18).
PMID: 37760568
Deregulation of the MYC family of transcription factors c-MYC (encoded by ), MYCN, and MYCL is prevalent in most human cancers, with an impact on tumor initiation and progression, as...
3.
Agarwal P, Glowacka A, Mahmoud L, Bazzar W, Larsson L, Alzrigat M
Int J Mol Sci
. 2023 May;
24(9).
PMID: 37175848
Amplification of the oncogene is found in ~20% of neuroblastoma (NB) cases and correlates with high-risk disease and poor prognosis. Despite the plethora of studies describing the role of MYCN...
4.
Castell A, Yan Q, Fawkner K, Bazzar W, Zhang F, Wickstrom M, et al.
Cancer Res Commun
. 2023 Mar;
2(3):182-201.
PMID: 36874405
Significance: Our findings demonstrate that the small-molecule MYCMI-7 binds MYC and inhibits interaction between MYC and MAX, thereby hampering MYC-driven tumor cell growth in culture and while sparing normal cells.
5.
Masso-Valles D, Beaulieu M, Jauset T, Giuntini F, Zacarias-Fluck M, Foradada L, et al.
Cancer Res Commun
. 2023 Mar;
2(2):110-130.
PMID: 36860495
Significance: While MYC role in metastasis has been long controversial, this manuscript demonstrates that MYC inhibition by either transgenic expression or pharmacologic use of the recombinantly produced Omomyc miniprotein exerts...
6.
Liu R, Muliadi V, Mou W, Li H, Yuan J, Holmberg J, et al.
Nat Commun
. 2022 Nov;
13(1):6545.
PMID: 36319641
No abstract available.
7.
Liu R, Muliadi V, Mou W, Li H, Yuan J, Holmberg J, et al.
Nat Commun
. 2022 Sep;
13(1):5093.
PMID: 36064840
The hypoxia-inducible factors (HIFs) regulate the main transcriptional pathway of response to hypoxia in T cells and are negatively regulated by von Hippel-Lindau factor (VHL). But the role of HIFs...
8.
Zhang F, Bazzar W, Alzrigat M, Larsson L
Methods Mol Biol
. 2021 May;
2318:241-254.
PMID: 34019294
Cellular senescence plays a role in several physiological processes including aging, embryonic development, tissue remodeling, and wound healing and is considered one of the main barriers against tumor development. Studies...
9.
Bazzar W, Bocci M, Hejll E, Hogqvist Tabor V, Hydbring P, Grandien A, et al.
Cell Cycle
. 2020 Dec;
20(1):23-38.
PMID: 33356836
Deregulated expression of the MYC oncogene is a frequent event during tumorigenesis and generally correlates with aggressive disease and poor prognosis. While MYC is a potent inducer of apoptosis, it...
10.
Alzrigat M, Jernberg-Wiklund H, Licht J
Epigenomes
. 2019 Feb;
2(3).
PMID: 30761216
The enhancer of zeste homolog 2 (EZH2) is the enzymatic subunit of the polycomb repressive complex 2 (PRC2) that exerts important functions during normal development as well as disease. PRC2...