Helena C Brown
Overview
Explore the profile of Helena C Brown including associated specialties, affiliations and a list of published articles.
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5
Citations
24
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Recent Articles
1.
Smith C, Campos J, Brown H, Jooss N, Ivanova V, Harbi M, et al.
Blood Adv
. 2024 Jul;
8(21):5557-5570.
PMID: 38968150
Platelet C-type lectin-like receptor 2 (CLEC-2) is a hem-immunoreceptor tyrosine-based activation motif-containing receptor that has a critical role in venous thrombosis but minimal involvement in hemostasis. CLEC-2 can be blocked...
2.
Clark J, Martin E, Moran L, Di Y, Wang X, Zuidscherwoude M, et al.
Commun Biol
. 2023 Apr;
6(1):376.
PMID: 37029319
CLEC-2 is a target for a new class of antiplatelet agent. Clustering of CLEC-2 leads to phosphorylation of a cytosolic YxxL and binding of the tandem SH2 domains in Syk,...
3.
Brown H, Beck S, Navarro S, Di Y, Soriano Jerez E, Kaczmarzyk J, et al.
Blood Adv
. 2022 Aug;
7(6):997-1000.
PMID: 36044387
No abstract available.
4.
Bourne J, Smith C, Jooss N, Di Y, Brown H, Montague S, et al.
Thromb Haemost
. 2022 Jul;
122(12):1988-2000.
PMID: 35817083
C-type lectin-like receptor 2 (CLEC-2) is highly expressed on platelets and a subpopulation of myeloid cells, and is critical in lymphatic development. CLEC-2 has been shown to support thrombus formation...
5.
Perrella G, Montague S, Brown H, Garcia Quintanilla L, Slater A, Stegner D, et al.
Int J Mol Sci
. 2022 Jan;
23(1).
PMID: 35008919
Understanding the pathways involved in the formation and stability of the core and shell regions of a platelet-rich arterial thrombus may result in new ways to treat arterial thrombosis. The...