David Stegner
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Explore the profile of David Stegner including associated specialties, affiliations and a list of published articles.
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104
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2179
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Recent Articles
1.
Hackenbroch C, Cimen T, Gross C, Rubenzucker S, Burkard P, Gross N, et al.
Blood Adv
. 2025 Mar;
PMID: 40048739
No abstract available.
2.
Starke A, Kollikowski A, Vogt V, Stoll G, Nieswandt B, Pham M, et al.
Biomedicines
. 2024 Oct;
12(10).
PMID: 39457504
Severe acute ischemic stroke (AIS) is mainly caused by thromboembolism originating from symptomatic carotid artery (ICA) stenosis or in the heart due to atrial fibrillation. Glycoprotein VI (GPVI), a principal...
3.
Dense but not alpha granules of platelets are required for insulin secretion from pancreatic β cells
Kolczynska-Matysiak K, Karwen T, Loeffler M, Hawro I, Kassouf T, Stegner D, et al.
Biochem Biophys Res Commun
. 2024 Oct;
734:150753.
PMID: 39366180
Objectives: Platelets, originally described for their role in blood coagulation, are now also recognized as key players in modulating inflammation, tissue regeneration, angiogenesis, and carcinogenesis. Recent evidence suggests that platelets...
4.
Rodriguez Moore G, Melo-Escobar I, Stegner D, Bracko O
Mol Neurodegener
. 2024 Sep;
19(1):65.
PMID: 39334369
Alzheimer's disease (AD) and related dementias (ADRD) collectively affect a significant portion of the aging population worldwide. The pathological progression of AD involves not only the classical hallmarks of amyloid...
5.
de Jonckheere B, Kollotzek F, Munzer P, Gob V, Fischer M, Mott K, et al.
Nat Cardiovasc Res
. 2024 Aug;
2(12):1327.
PMID: 39196157
No abstract available.
6.
Stegner D, Gob V, Krenzlin V, Beck S, Hemmen K, Schuhmann M, et al.
Nat Cardiovasc Res
. 2024 Aug;
1(2):132-141.
PMID: 39195988
Cerebral venous (sinus) thrombosis (CVT) is an unusual manifestation of venous thrombosis causing severe neurological impairment and seizures. Molecular mechanisms underlying CVT, potentially involving pathological platelet activation, are unknown. Here...
7.
Navarro S, Talucci I, Gob V, Hartmann S, Beck S, Orth V, et al.
Eur Heart J
. 2024 Aug;
45(43):4582-4597.
PMID: 39150906
Background And Aims: Glycoprotein VI (GPVI) is a platelet collagen/fibrin(ogen) receptor and an emerging pharmacological target for the treatment of thrombotic and thrombo-inflammatory diseases, notably ischaemic stroke. A first anti-human...
8.
Li L, Stegner D
Res Pract Thromb Haemost
. 2024 Mar;
8(1):102344.
PMID: 38433977
A State-of-the Art lecture titled "Thrombo-Neuroinflammatory Disease" was presented at the International Society on Thrombosis and Haemostasis Congress in 2023. First, we would like to advocate for discrimination between immunothrombosis...
9.
Liu W, Pircher J, Schuermans A, Ain Q, Zhang Z, Honigberg M, et al.
Blood
. 2023 Dec;
143(15):1539-1550.
PMID: 38142422
JAK2 V617F (JAK2VF) clonal hematopoiesis (CH) has been associated with atherothrombotic cardiovascular disease (CVD). We assessed the impact of Jak2VF CH on arterial thrombosis and explored the underlying mechanisms. A...
10.
de Jonckheere B, Kollotzek F, Munzer P, Gob V, Fischer M, Mott K, et al.
Nat Cardiovasc Res
. 2023 Dec;
2:835-852.
PMID: 38075556
During megakaryopoiesis, megakaryocytes (MK) undergo cellular morphological changes with strong modification of membrane composition and lipid signaling. Here we adopt a lipid-centric multiomics approach to create a quantitative map of...