Helen Whiteland
Overview
Explore the profile of Helen Whiteland including associated specialties, affiliations and a list of published articles.
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11
Citations
140
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Recent Articles
1.
Schiedel M, McArdle D, Padalino G, Chan A, Forde-Thomas J, McDonough M, et al.
J Med Chem
. 2023 Dec;
66(23):15801-15822.
PMID: 38048437
Schistosomiasis is a disease affecting >200 million people worldwide, but its treatment relies on a single agent, praziquantel. To investigate new avenues for schistosomiasis control, we have conducted the first...
2.
Padalino G, El-Sakkary N, Liu L, Liu C, Harte D, Barnes R, et al.
Eur J Med Chem
. 2021 Sep;
226:113823.
PMID: 34536671
Schistosomiasis is a neglected disease of poverty that is caused by infection with blood fluke species contained within the genus Schistosoma. For the last 40 years, control of schistosomiasis in...
3.
Partridge F, Bataille C, Forman R, Marriott A, Forde-Thomas J, Haberli C, et al.
ACS Infect Dis
. 2021 Apr;
7(5):1260-1274.
PMID: 33797218
Nine hundred million people are infected with the soil-transmitted helminths (roundworm), hookworm, and (whipworm). However, low single-dose cure rates of the benzimidazole drugs, the mainstay of preventative chemotherapy for whipworm,...
4.
Craven H, Bonsignore R, Lenis V, Santi N, Berrar D, Swain M, et al.
PLoS Negl Trop Dis
. 2021 Feb;
15(2):e0008770.
PMID: 33600427
Schistosomiasis is a neglected tropical disease that currently affects over 250 million individuals worldwide. In the absence of an immunoprophylactic vaccine and the recognition that mono-chemotherapeutic control of schistosomiasis by...
5.
Whiteland H, Crusco A, Bloemberg L, Tibble-Howlings J, Forde-Thomas J, Coghlan A, et al.
PLoS Negl Trop Dis
. 2020 Oct;
14(10):e0008630.
PMID: 33075069
Background: Schistosomiasis is a prevalent neglected tropical disease that affects approximately 300 million people worldwide. Its treatment is through a single class chemotherapy, praziquantel. Concerns surrounding the emergence of praziquantel...
6.
Whatley K, Padalino G, Whiteland H, Geyer K, Hulme B, Chalmers I, et al.
PLoS Negl Trop Dis
. 2019 Nov;
13(11):e0007693.
PMID: 31730617
Background: Praziquantel represents the frontline chemotherapy used to treat schistosomiasis, a neglected tropical disease (NTD) caused by infection with macro-parasitic blood fluke schistosomes. While this drug is safe, its inability...
7.
Younas K, Quintela M, Thomas S, Garcia-Parra J, Blake L, Whiteland H, et al.
J Mol Med (Berl)
. 2019 Jul;
97(9):1315-1327.
PMID: 31256208
Polycystic ovary syndrome (PCOS) is a common gynaecological disorder, with a prevalence of up to 12% of women of reproductive age, and is in part characterised by elevated circulating androgens...
8.
Crusco A, Whiteland H, Baptista R, Forde-Thomas J, Beckmann M, Mur L, et al.
ACS Infect Dis
. 2019 May;
5(7):1188-1199.
PMID: 31083889
Sclareol, a plant-derived diterpenoid widely used as a fragrance and flavoring substance, is well-known for its promising antimicrobial and anticancer properties. However, its activity on helminth parasites has not been...
9.
Crusco A, Bordoni C, Chakroborty A, Whatley K, Whiteland H, Westwell A, et al.
Eur J Med Chem
. 2018 Apr;
152:87-100.
PMID: 29698860
The plant-derived, diterpenoid 7-keto-sempervirol was recently reported to display moderate activity against larval stages of Schistosoma mansoni (IC = 19.1 μM) and Fasciola hepatica (IC = 17.7 μM), two related...
10.
Whiteland H, Spencer-Harty S, Morgan C, Kynaston H, Thomas D, Bose P, et al.
Clin Exp Metastasis
. 2014 Sep;
31(8):909-20.
PMID: 25248617
Prostate adenocarcinoma is the second most frequent cancer worldwide and is one of the leading causes of male cancer-related deaths. However, it varies greatly in its behaviour, from indolent non-progressive...