Andrew D Westwell
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Explore the profile of Andrew D Westwell including associated specialties, affiliations and a list of published articles.
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90
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1223
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Recent Articles
1.
Seaton G, Smith H, Brancale A, Westwell A, Clarkson R
Mol Cancer
. 2024 Jan;
23(1):7.
PMID: 38195591
In the early 1990's a group of unrelated genes were identified from the sites of recurring translocations in B-cell lymphomas. Despite sharing the nomenclature 'Bcl', and an association with blood-borne...
2.
Almehdi A, Soliman S, El-Shorbagi A, Westwell A, Hamdy R
Int J Mol Sci
. 2023 Oct;
24(19).
PMID: 37834104
The Bcl-2 family plays a crucial role in regulating cell apoptosis, making it an attractive target for cancer therapy. In this study, a series of indole-based compounds, -, were designed,...
3.
Hamdy R, Jones A, El-Sadek M, Hamoda A, Shakartalla S, Al Shareef Z, et al.
Int J Mol Sci
. 2021 Nov;
22(22).
PMID: 34830153
A series of 3-(6-substituted phenyl-[1,2,4]-triazolo[3,4-b]-[1,3,4]-thiadiazol-3-yl)-1H-indoles (-) were designed, synthesized and evaluated for anti-apoptotic Bcl-2-inhibitory activity. Synthesis of the target compounds was readily accomplished through a reaction of acyl hydrazide ()...
4.
Scurr M, Zelek W, Lippiatt G, Somerville M, Burnell S, Capitani L, et al.
Immunology
. 2021 Nov;
165(2):250-259.
PMID: 34775604
Accurate assessment of SARS-CoV-2 immunity is critical in evaluating vaccine efficacy and devising public health policies. Whilst the exact nature of effective immunity remains incompletely defined, SARS-CoV-2-specific T-cell responses are...
5.
Soukupova J, Bordoni C, Turnham D, Yang W, Seaton G, Gruca A, et al.
Mol Cancer Ther
. 2021 Mar;
20(5):775-786.
PMID: 33649105
The development of antimetastatic drugs is an urgent healthcare priority for patients with cancer, because metastasis is thought to account for around 90% of cancer deaths. Current antimetastatic treatment options...
6.
Kandil S, Kariuki B, McGuigan C, Westwell A
Bioorg Med Chem Lett
. 2021 Jan;
36:127817.
PMID: 33513386
The androgen receptor (AR) is a pivotal target for the treatment of prostate cancer (PC) even when the disease progresses toward androgen-independent or castration-resistant forms. In this study, a series...
7.
Kandil S, McGuigan C, Westwell A
Molecules
. 2020 Dec;
26(1).
PMID: 33374450
The androgen receptor (AR) is a pivotal target for the treatment of prostate cancer (PC) even when the disease progresses toward androgen-independent or castration-resistant forms. In this study, a series...
8.
Hamdy R, Elseginy S, Ziedan N, El-Sadek M, Lashin E, Jones A, et al.
Int J Mol Sci
. 2020 Dec;
21(23).
PMID: 33256166
A series of 2-(1-indol-3-yl)-5-substituted-1,3,4-oxadiazoles, were designed, synthesized and tested in vitro as potential pro-apoptotic Bcl-2 inhibitory anticancer agents based on our previously reported hit compounds. Synthesis of the target 1,3,4-oxadiazoles...
9.
Kandil S, Jones S, Smith S, Hiscox S, Westwell A
Molecules
. 2020 Aug;
25(15).
PMID: 32751931
Focal adhesion kinase (FAK) is a tyrosine kinase that is overexpressed and activated in several advanced-stage solid cancers. In cancer cells, FAK promotes the progression and metastasis of tumours. In...
10.
Shirinzadeh H, Suzen S, Altanlar N, Westwell A
Turk J Pharm Sci
. 2020 May;
15(3):291-297.
PMID: 32454672
Objectives: In new antimicrobial drug development studies, indole and its derivatives create an important class of compounds. In addition, azoles and their derivatives were recognized to be associated with a...