Helen M Sheldrake
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Explore the profile of Helen M Sheldrake including associated specialties, affiliations and a list of published articles.
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19
Citations
197
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Recent Articles
1.
Throup A, Zraikat M, Gordon A, Jafarinejad Soumehsaraei S, Haase K, Patterson L, et al.
RSC Med Chem
. 2024 Sep;
PMID: 39281803
The integrin family of cell surface extracellular matrix binding proteins are key to several physiological processes involved in tissue development, as well as cancer proliferation and dissemination. They are therefore...
2.
Boz Er A, Sheldrake H, Sutherland M
Int J Mol Sci
. 2024 Jul;
25(14).
PMID: 39063187
Metastatic melanoma, a deadly form of skin cancer, often develops resistance to the BRAF inhibitor drug vemurafenib, highlighting the need for understanding the underlying mechanisms of resistance and exploring potential...
3.
Sutherland M, Gordon A, Al-Shammari F, Throup A, La Corte A, Philippou H, et al.
Cancers (Basel)
. 2023 Aug;
15(16).
PMID: 37627051
The Arg-Gly-Asp (RGD)-binding family of integrin receptors, and notably the β3 subfamily, are key to multiple physiological processes involved in tissue development, cancer proliferation, and metastatic dissemination. While there is...
4.
Ortuzar N, Karu K, Presa D, Morais G, Sheldrake H, Shnyder S, et al.
Bioorg Med Chem
. 2021 May;
40:116167.
PMID: 33932713
The duocarmycins belong to a class of agent which has great potential for use in cancer therapy. Their exquisite potency means they are too toxic for systemic use, and targeted...
5.
Santos A, Sheldrake H, Ibrahim A, Danta C, Bonanni D, Daga M, et al.
Medchemcomm
. 2019 Nov;
10(8):1476-1480.
PMID: 31673310
Tetrahydroisoquinoline (THIQ) is a key structural component in many biologically active molecules including natural products and synthetic pharmaceuticals. Here, we report on the use of transition-metal mediated [2 + 2...
6.
Ahmedah H, Patterson L, Shnyder S, Sheldrake H
Cancers (Basel)
. 2017 Jun;
9(6).
PMID: 28587135
Alterations in integrin expression and function promote tumour growth, invasion, metastasis and neoangiogenesis. Head and neck cancers are highly vascular tumours with a tendency to metastasise. They express a wide...
7.
Throup A, Patterson L, Sheldrake H
Org Biomol Chem
. 2016 Oct;
14(40):9554-9559.
PMID: 27722445
Fused cyclobutanes are found in a range of natural products and formation of these motifs in a straightforward and easy manner represents an interesting synthetic challenge. To this end we...
8.
Sheldrake H, Patterson L
J Med Chem
. 2014 Feb;
57(15):6301-15.
PMID: 24568695
The integrins are a family of 24 heterodimeric transmembrane cell surface receptors. Involvement in cell attachment to the extracellular matrix, motility, and proliferation identifies integrins as therapeutic targets in cancer...
9.
Sutherland M, Gordon A, Shnyder S, Patterson L, Sheldrake H
Cancers (Basel)
. 2013 Nov;
4(4):1106-45.
PMID: 24213501
Prostate cancer is the third leading cause of male cancer deaths in the developed world. The current lack of highly specific detection methods and efficient therapeutic agents for advanced disease...
10.
Sheldrake H, Travica S, Johansson I, Loadman P, Sutherland M, Elsalem L, et al.
J Med Chem
. 2013 Jul;
56(15):6273-7.
PMID: 23844629
A library of duocarmycin bioprecursors based on the CPI and CBI scaffolds was synthesized and used to probe selective activation by cells expressing CYP1A1 and 2W1, CYPs known to be...