Helen M Sheldrake
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Explore the profile of Helen M Sheldrake including associated specialties, affiliations and a list of published articles.
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19
Citations
197
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Recent Articles
11.
Travica S, Pors K, Loadman P, Shnyder S, Johansson I, Alandas M, et al.
Clin Cancer Res
. 2013 Apr;
19(11):2952-61.
PMID: 23589180
Purpose: Cytochrome P450 2W1 (CYP2W1) is a monooxygenase detected in 30% of colon cancers, whereas its expression in nontransformed adult tissues is absent, rendering it a tumor-specific drug target for...
12.
Sutherland M, Gill J, Loadman P, Laye J, Sheldrake H, Illingworth N, et al.
Mol Cancer Ther
. 2012 Oct;
12(1):27-37.
PMID: 23033491
We identify cytochrome P450 1A1 (CYP1A1) as a target for tumor-selective drug development in bladder cancer and describe the characterization of ICT2700, designed to be metabolized from a prodrug to...
13.
Pors K, Loadman P, Shnyder S, Sutherland M, Sheldrake H, Guino M, et al.
Chem Commun (Camb)
. 2011 Oct;
47(44):12062-4.
PMID: 22002321
The identification of an agent that is selectively activated by a cytochrome P450 (CYP) has the potential for tissue specific dose intensification as a means of significantly improving its therapeutic...
14.
Ghosh N, Sheldrake H, Searcey M, Pors K
Curr Top Med Chem
. 2009 Nov;
9(16):1494-524.
PMID: 19903166
CC-1065, the duocarmycins and yatakemycin are members of a family of ultrapotent antitumour antibiotics that have been the subject of extensive investigations due to their mode of action and potential...
15.
Sheldrake H, Jamieson C, Pascu S, Burton J
Org Biomol Chem
. 2008 Dec;
7(2):238-52.
PMID: 19109668
A bidirectional synthesis of the originally proposed structures for the natural products elatenyne and a chloroenyne from Laurencia majuscula is described along with a reassessment of the structures of the...
16.
Edwards D, House D, Sheldrake H, Stone S, Wallace T
Org Biomol Chem
. 2007 Nov;
5(16):2658-69.
PMID: 18019541
The condensation of a 2-substituted-2-aminoethanol with methyl 2'-formylbiphenyl-2-carboxylate produces only two of the four possible axially chiral 6,7-dihydrodibenz[c,e]oxazolo[3,2-a]azepin-9(4bH)-ones (fused oxazolidine lactams), with kinetically controlled diastereoisomer ratios of up to 96...
17.
Sheldrake H, Jamieson C, Burton J
Angew Chem Int Ed Engl
. 2006 Oct;
45(43):7199-202.
PMID: 17024712
No abstract available.
18.
Sheldrake H, Wallace T, Wilson C
Org Lett
. 2005 Sep;
7(19):4233-6.
PMID: 16146395
[reaction: see text] Enamine [2 + 2] cycloadditions can be achieved in useful yields simply by stirring a mixture of an aldehyde, diethylamine, a dialkyl fumarate, and potassium carbonate in...
19.
Hulcoop D, Sheldrake H, Burton J
Org Biomol Chem
. 2004 Mar;
2(7):965-7.
PMID: 15034618
Unsaturated malonates bearing pendant alcohols yield carbocycles tethered to oxygen heterocycles on exposure to manganese(iii) acetate and an appropriate copper(ii) salt.