Heinrich Kroukamp
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Explore the profile of Heinrich Kroukamp including associated specialties, affiliations and a list of published articles.
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12
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92
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Recent Articles
1.
Construction and iterative redesign of synXVI a 903 kb synthetic Saccharomyces cerevisiae chromosome
Goold H, Kroukamp H, Erpf P, Zhao Y, Kelso P, Calame J, et al.
Nat Commun
. 2025 Jan;
16(1):841.
PMID: 39833175
The Sc2.0 global consortium to design and construct a synthetic genome based on the Saccharomyces cerevisiae genome commenced in 2006, comprising 16 synthetic chromosomes and a new-to-nature tRNA neochromosome. In...
2.
Williams T, Kroukamp H, Xu X, Wightman E, Llorente B, Borneman A, et al.
Cell Genom
. 2023 Nov;
3(11):100379.
PMID: 38020977
Synthetic chromosome engineering is a complex process due to the need to identify and repair growth defects and deal with combinatorial gene essentiality when rearranging chromosomes. To alleviate these issues,...
3.
Timmins J, van Wyk N, Kroukamp H, Walker R, Fritsch S, Rauhut D, et al.
FEMS Yeast Res
. 2023 Jan;
23.
PMID: 36708173
Wine is composed of multitudinous flavour components and volatile organic compounds that provide this beverage with its attractive properties of taste and aroma. The perceived quality of a wine can...
4.
Kroukamp H, Peng K, Paulsen I, den Haan R
Methods Mol Biol
. 2022 Jan;
2378:19-30.
PMID: 34985691
The unfolded protein response (UPR) is a highly conserved protein quality control mechanism of eukaryotic cells. Aberrations in this response have been linked to several human diseases, including retinitis pigmentosa...
5.
Peng K, Kroukamp H, Pretorius I, Paulsen I
ACS Synth Biol
. 2021 Jun;
10(7):1640-1650.
PMID: 34126009
The unfolded protein response (UPR) is a highly conserved cellular response in eukaryotic cells to counteract endoplasmic reticulum (ER) stress, typically triggered by unfolded protein accumulation. In addition to its...
6.
Wightman E, Kroukamp H, Pretorius I, Paulsen I, Nevalainen H
Biotechnol Biofuels
. 2020 Dec;
13(1):182.
PMID: 33292481
Background: For the economic production of biofuels and other valuable products from lignocellulosic waste material, a consolidated bioprocessing (CBP) organism is required. With efficient fermentation capability and attractive industrial qualities,...
7.
Wightman E, Kroukamp H, Pretorius I, Paulsen I, Nevalainen H
Microorganisms
. 2020 Dec;
8(12).
PMID: 33271913
Genome-scale engineering and custom synthetic genomes are reshaping the next generation of industrial yeast strains. The Cre-recombinase-mediated chromosomal rearrangement mechanism of designer synthetic chromosomes, known as SCRaMbLE, is a powerful...
8.
Timmins J, Kroukamp H, Paulsen I, Pretorius I
Molecules
. 2020 Jun;
25(12).
PMID: 32560189
Olfactory cues are key drivers of our multisensory experiences of food and drink. For example, our perception and enjoyment of the flavour and taste of a wine is primarily steered...
9.
van Wyk N, Kroukamp H, Espinosa M, von Wallbrunn C, Wendland J, Pretorius I
Int J Food Microbiol
. 2020 May;
324:108615.
PMID: 32371236
In recent years, CRISPR/Cas9-based genetic editing has become a mainstay in many laboratories including manipulations done with yeast. We utilized this technique to generate a self-cloned wine yeast strain that...
10.
Cedras G, Kroukamp H, van Zyl W, den Haan R
Biotechnol Appl Biochem
. 2019 Sep;
67(1):82-94.
PMID: 31523843
The yeast Saccharomyces cerevisiae possesses industrially desirable traits for ethanol production and has been engineered for consolidated bioprocessing (CBP) of lignocellulosic biomass through heterologous cellulase expression. However, S. cerevisiae produces...