Elizabeth L I Wightman
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Explore the profile of Elizabeth L I Wightman including associated specialties, affiliations and a list of published articles.
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3
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14
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Recent Articles
1.
Construction and iterative redesign of synXVI a 903 kb synthetic Saccharomyces cerevisiae chromosome
Goold H, Kroukamp H, Erpf P, Zhao Y, Kelso P, Calame J, et al.
Nat Commun
. 2025 Jan;
16(1):841.
PMID: 39833175
The Sc2.0 global consortium to design and construct a synthetic genome based on the Saccharomyces cerevisiae genome commenced in 2006, comprising 16 synthetic chromosomes and a new-to-nature tRNA neochromosome. In...
2.
Williams T, Kroukamp H, Xu X, Wightman E, Llorente B, Borneman A, et al.
Cell Genom
. 2023 Nov;
3(11):100379.
PMID: 38020977
Synthetic chromosome engineering is a complex process due to the need to identify and repair growth defects and deal with combinatorial gene essentiality when rearranging chromosomes. To alleviate these issues,...
3.
Wightman E, Kroukamp H, Pretorius I, Paulsen I, Nevalainen H
Biotechnol Biofuels
. 2020 Dec;
13(1):182.
PMID: 33292481
Background: For the economic production of biofuels and other valuable products from lignocellulosic waste material, a consolidated bioprocessing (CBP) organism is required. With efficient fermentation capability and attractive industrial qualities,...
4.
Wightman E, Kroukamp H, Pretorius I, Paulsen I, Nevalainen H
Microorganisms
. 2020 Dec;
8(12).
PMID: 33271913
Genome-scale engineering and custom synthetic genomes are reshaping the next generation of industrial yeast strains. The Cre-recombinase-mediated chromosomal rearrangement mechanism of designer synthetic chromosomes, known as SCRaMbLE, is a powerful...