Heidrun Ellinger-Ziegelbauer
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Explore the profile of Heidrun Ellinger-Ziegelbauer including associated specialties, affiliations and a list of published articles.
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51
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858
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Recent Articles
1.
Kraehling J, Benardeau A, Schomber T, Popp L, Vienenkoetter J, Ellinger-Ziegelbauer H, et al.
Int J Mol Sci
. 2023 Sep;
24(17).
PMID: 37686032
Chronic kidney disease (CKD) progression is associated with persisting oxidative stress, which impairs the NO-sGC-cGMP signaling cascade through the formation of oxidized and heme-free apo-sGC that cannot be activated by...
2.
Buick J, Rowan-Carroll A, Gagne R, Williams A, Chen R, Li H, et al.
Front Toxicol
. 2022 Oct;
4:991590.
PMID: 36211197
Genotoxicity testing relies on the detection of gene mutations and chromosome damage and has been used in the genetic safety assessment of drugs and chemicals for decades. However, the results...
3.
Corton J, Mitchell C, Auerbach S, Bushel P, Ellinger-Ziegelbauer H, Escobar P, et al.
Toxicol Sci
. 2022 Apr;
188(1):4-16.
PMID: 35404422
There is growing recognition across broad sectors of the scientific community that use of genomic biomarkers has the potential to reduce the need for conventional rodent carcinogenicity studies of industrial...
4.
Petzuch B, Benardeau A, Hofmeister L, Meyer J, Hartmann E, Pavkovic M, et al.
Toxicol Sci
. 2022 Mar;
187(1):35-50.
PMID: 35244176
Micro-RNAs (miRNAs) are regulators of gene expression and play an important role in physiological homeostasis and disease. In biofluids, miRNAs can be found in protein complexes or in extracellular vesicles...
5.
A cross-industry survey on photosafety evaluation of pharmaceuticals after implementation of ICH S10
Bauer D, Buckley L, Delafoy L, Ellinger-Ziegelbauer H, Fellows M, Gerets H, et al.
Regul Toxicol Pharmacol
. 2021 Jul;
125:105017.
PMID: 34311056
A cross-industry survey was conducted by EFPIA/IQ DruSafe in 2018 to provide information on photosafety evaluation of pharmaceuticals after implementation of ICH S10. This survey focused on the strategy utilized...
6.
Chorley B, Atabakhsh E, Doran G, Gautier J, Ellinger-Ziegelbauer H, Jackson D, et al.
Crit Rev Toxicol
. 2021 May;
51(3):264-282.
PMID: 34038674
MicroRNAs (miRNAs) are small non-coding RNA that regulate the expression of messenger RNA and are implicated in almost all cellular processes. Importantly, miRNAs can be released extracellularly and are stable...
7.
Li H, Yauk C, Chen R, Hyduke D, Williams A, Frotschl R, et al.
Front Big Data
. 2021 Mar;
2:36.
PMID: 33693359
Genotoxicity testing is an essential component of the safety assessment paradigm required by regulatory agencies world-wide for analysis of drug candidates, and environmental and industrial chemicals. Current genotoxicity testing batteries...
8.
Urinary miRNA Biomarkers of Drug-Induced Kidney Injury and Their Site Specificity Within the Nephron
Chorley B, Ellinger-Ziegelbauer H, Tackett M, Simutis F, Harrill A, McDuffie J, et al.
Toxicol Sci
. 2020 Dec;
180(1):1-16.
PMID: 33367795
Drug-induced kidney injury (DIKI) is a major concern in both drug development and clinical practice. There is an unmet need for biomarkers of glomerular damage and more distal renal injury...
9.
Yauk C, Harrill A, Ellinger-Ziegelbauer H, van der Laan J, Moggs J, Froetschl R, et al.
Regul Toxicol Pharmacol
. 2019 Nov;
110:104526.
PMID: 31726190
Robust genomic approaches are now available to realize improvements in efficiencies and translational relevance of cancer risk assessments for drugs and chemicals. Mechanistic and pathway data generated via genomics provide...
10.
Heinz S, Freyberger A, Lawrenz B, Schladt L, Schmuck G, Ellinger-Ziegelbauer H
Arch Toxicol
. 2019 Jul;
93(9):2603-2615.
PMID: 31324951
The biguanide metformin, a widely used antidiabetic drug, has received great interest in oncology research in recent years after an epidemiological study showed a link between metformin treatment and a...