Alison H Harrill
Overview
Explore the profile of Alison H Harrill including associated specialties, affiliations and a list of published articles.
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31
Citations
618
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Recent Articles
1.
Harrill A, Samedy-Bates L, Pawlyk A, Ren Z
J Clin Pharmacol
. 2022 Sep;
62 Suppl 1:S9-S11.
PMID: 36106787
No abstract available.
2.
Corton J, Mitchell C, Auerbach S, Bushel P, Ellinger-Ziegelbauer H, Escobar P, et al.
Toxicol Sci
. 2022 Apr;
188(1):4-16.
PMID: 35404422
There is growing recognition across broad sectors of the scientific community that use of genomic biomarkers has the potential to reduce the need for conventional rodent carcinogenicity studies of industrial...
3.
Chorley B, Atabakhsh E, Doran G, Gautier J, Ellinger-Ziegelbauer H, Jackson D, et al.
Crit Rev Toxicol
. 2021 May;
51(3):264-282.
PMID: 34038674
MicroRNAs (miRNAs) are small non-coding RNA that regulate the expression of messenger RNA and are implicated in almost all cellular processes. Importantly, miRNAs can be released extracellularly and are stable...
4.
Urinary miRNA Biomarkers of Drug-Induced Kidney Injury and Their Site Specificity Within the Nephron
Chorley B, Ellinger-Ziegelbauer H, Tackett M, Simutis F, Harrill A, McDuffie J, et al.
Toxicol Sci
. 2020 Dec;
180(1):1-16.
PMID: 33367795
Drug-induced kidney injury (DIKI) is a major concern in both drug development and clinical practice. There is an unmet need for biomarkers of glomerular damage and more distal renal injury...
5.
Skelly D, Czechanski A, Byers C, Aydin S, Spruce C, Olivier C, et al.
Cell Stem Cell
. 2020 Aug;
27(3):459-469.e8.
PMID: 32795400
Mouse embryonic stem cells (mESCs) cultured in the presence of LIF occupy a ground state with highly active pluripotency-associated transcriptional and epigenetic circuitry. However, ground state pluripotency in some inbred...
6.
You D, Lyn-Cook L, Gatti D, Bell N, Mayeux P, James L, et al.
Toxicol Sci
. 2020 Mar;
175(2):220-235.
PMID: 32170957
Zileuton is an orally active inhibitor of leukotriene synthesis for maintenance treatment of asthma, for which clinical usage has been associated with idiosyncratic liver injury. Mechanistic understanding of zileuton toxicity...
7.
Harrill A, Sanders A
Curr Environ Health Rep
. 2020 Mar;
7(2):101-108.
PMID: 32166731
Purpose Of Review: There is a critical need for sensitive biomarkers of renal disease and progression. Micro(mi)RNAs are attractive as next-generation biomarkers in kidney disease, particularly as urine miRNAs can...
8.
Bushel P, Caiment F, Wu H, OLone R, Day F, Calley J, et al.
RNA Biol
. 2020 Feb;
17(5):630-636.
PMID: 32009518
MicroRNAs (miRNAs) are small RNAs that regulate mRNA expression and have been targeted as biomarkers of organ damage and disease. To explore the utility of miRNAs to assess injury to...
9.
10.
Yauk C, Harrill A, Ellinger-Ziegelbauer H, van der Laan J, Moggs J, Froetschl R, et al.
Regul Toxicol Pharmacol
. 2019 Nov;
110:104526.
PMID: 31726190
Robust genomic approaches are now available to realize improvements in efficiencies and translational relevance of cancer risk assessments for drugs and chemicals. Mechanistic and pathway data generated via genomics provide...