Hayley Whitfield
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Explore the profile of Hayley Whitfield including associated specialties, affiliations and a list of published articles.
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12
Citations
91
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Recent Articles
1.
Marquez-Monino M, Ortega-Garcia R, Whitfield H, Riley A, Infantes L, Garrett S, et al.
Nat Commun
. 2024 Feb;
15(1):1502.
PMID: 38374076
D-myo-inositol 1,4,5-trisphosphate (InsP) is a fundamental second messenger in cellular Ca mobilization. InsP 3-kinase, a highly specific enzyme binding InsP in just one mode, phosphorylates InsP specifically at its secondary...
2.
Sprigg C, Whitfield H, Burton E, Scholey D, Bedford M, Brearley C
PLoS One
. 2022 Oct;
17(10):e0275742.
PMID: 36260560
Phytases, enzymes that degrade phytate present in feedstuffs, are widely added to the diets of monogastric animals. Many studies have correlated phytase addition with improved animal productivity and a subset...
3.
Rix G, Sprigg C, Whitfield H, Hemmings A, Todd J, Brearley C
PLoS One
. 2022 Aug;
17(8):e0272015.
PMID: 36044476
Phylogenetic analysis, homology modelling and biochemical methods have been employed to characterize a phytase from a Gram-negative soil bacterium. Acinetobacter sp. AC1-2 phytase belongs to clade 2 of the histidine...
4.
Whitfield H, Hemmings A, Mills S, Baker K, White G, Rushworth S, et al.
J Med Chem
. 2021 Mar;
64(7):3813-3826.
PMID: 33724834
Src homology 2 domain-containing inositol phosphate phosphatase 2 (SHIP2) is one of the 10 human inositol phosphate 5-phosphatases. One of its physiological functions is dephosphorylation of phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4,5)P. It...
5.
Whitfield H, White G, Sprigg C, Riley A, Potter B, Hemmings A, et al.
Biochem J
. 2020 Jul;
477(14):2621-2638.
PMID: 32706850
Inositol polyphosphates are ubiquitous molecular signals in metazoans, as are their pyrophosphorylated derivatives that bear a so-called 'high-energy' phosphoanhydride bond. A structural rationale is provided for the ability of Arabidopsis...
6.
White G, Prior C, Mills S, Baker K, Whitfield H, Riley A, et al.
ACS Med Chem Lett
. 2020 Mar;
11(3):309-315.
PMID: 32184962
SHIP2 (SH2-domain containing inositol 5-phosphatase type 2) is a canonical 5-phosphatase, which, through its catalytic action on PtdInsP, regulates the PI3K/Akt pathway and metabolic action of insulin. It is a...
7.
Greene E, Flees J, Dadgar S, Mallmann B, Orlowski S, Dhamad A, et al.
Front Physiol
. 2019 Oct;
10:1251.
PMID: 31632293
The incidence of woody breast (WB) is increasing on a global scale representing a significant welfare problem and economic burden to the poultry industry and for which there is no...
8.
Lu H, Kuhn I, Bedford M, Whitfield H, Brearley C, Adeola O, et al.
J Anim Sci
. 2019 Jul;
97(9):3907-3919.
PMID: 31294448
The objective of this present study was to determine the effects of phytase dosing on growth performance, mineral digestibility, phytate breakdown, and the level of glucose transporter type 4 (GLUT4)...
9.
Laird S, Kuhn I, Bedford M, Whitfield H, Miller H
Anim Nutr
. 2019 Jun;
5(2):196-201.
PMID: 31193977
This experiment was conducted to determine the effects of time and freezing temperature during sampling on gastric phytate (-inositol [MYO] hexakisphosphate [InsP]), lower inositol phosphates (InsP) and MYO concentrations in...
10.
Whitfield H, Gilmartin M, Baker K, Riley A, Godage H, Potter B, et al.
J Med Chem
. 2018 Aug;
61(19):8838-8846.
PMID: 30160967
Inositol pentakisphosphate 2-kinase catalyzes the phosphorylation of the axial 2-OH of myo-inositol 1,3,4,5,6-pentakisphosphate for de novo synthesis of myo-inositol hexakisphosphate. Disruption of inositol pentakisphosphate 2-kinase profoundly influences cellular processes, from...