Andrew M Riley
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Explore the profile of Andrew M Riley including associated specialties, affiliations and a list of published articles.
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64
Citations
828
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Recent Articles
1.
Liu X, Zhang Z, Aguirre T, Shipton M, Fu L, Du J, et al.
Metabolism
. 2024 Dec;
163:156098.
PMID: 39643078
Background And Aims: Atherosclerotic cardiovascular diseases are the leading cause of death. Apolipoprotein A-I (apoA-I) mediates cholesterol efflux to lower the risks of atherosclerosis. Elevating circulating apoA-I is an effective...
2.
Marquez-Monino M, Ortega-Garcia R, Whitfield H, Riley A, Infantes L, Garrett S, et al.
Nat Commun
. 2024 Feb;
15(1):1502.
PMID: 38374076
D-myo-inositol 1,4,5-trisphosphate (InsP) is a fundamental second messenger in cellular Ca mobilization. InsP 3-kinase, a highly specific enzyme binding InsP in just one mode, phosphorylates InsP specifically at its secondary...
3.
Fu L, Du J, Furkert D, Shipton M, Liu X, Aguirre T, et al.
Cardiovasc Res
. 2024 Jan;
120(8):954-970.
PMID: 38252884
Aims: Adiponectin is an adipocyte-derived circulating protein that exerts cardiovascular and metabolic protection. Due to the futile degradation of endogenous adiponectin and the challenges of exogenous administration, regulatory mechanisms of...
4.
Whitfield H, Rodriguez R, Shipton M, Li A, Riley A, Potter B, et al.
Biochemistry
. 2023 Dec;
63(1):42-52.
PMID: 38146842
Inositol phosphates and their pyrophosphorylated derivatives are responsive to the phosphate supply and are agents of phosphate homeostasis and other aspects of physiology. It seems likely that the enzymes that...
5.
Hostachy S, Wang H, Zong G, Franke K, Riley A, Schmieder P, et al.
Chemistry
. 2023 Sep;
29(67):e202302426.
PMID: 37773020
Inositol pyrophosphates (PP-IPs) are densely phosphorylated messenger molecules involved in numerous biological processes. PP-IPs contain one or two pyrophosphate group(s) attached to a phosphorylated myo-inositol ring. 5PP-IP is the most...
6.
Sacerdoti M, Gross L, Riley A, Zehnder K, Ghode A, Klinke S, et al.
Sci Signal
. 2023 Jun;
16(789):eadd3184.
PMID: 37311034
The activation of at least 23 different mammalian kinases requires the phosphorylation of their hydrophobic motifs by the kinase PDK1. A linker connects the phosphoinositide-binding PH domain to the catalytic...
7.
Shipton M, Jamion F, Wheeler S, Riley A, Plasser F, Potter B, et al.
Chem Sci
. 2023 May;
14(19):4979-4985.
PMID: 37206391
Inositol pyrophosphates are important biomolecules associated with apoptosis, cell growth and kinase regulation, yet their exact biological roles are still emerging and probes do not exist for their selective detection....
8.
Whitfield H, He S, Gu Y, Sprigg C, Kuo H, Chiou T, et al.
Biochem J
. 2023 Mar;
480(6):433-453.
PMID: 36896917
Myo-inositol tris/tetrakisphosphate kinases (ITPKs) catalyze diverse phosphotransfer reactions with myo-inositol phosphate and myo-inositol pyrophosphate substrates. However, the lack of structures of nucleotide-coordinated plant ITPKs thwarts a rational understanding of phosphotransfer...
9.
Qi J, Cheng W, Gao Z, Chen Y, Shipton M, Furkert D, et al.
Biomed Pharmacother
. 2023 Mar;
161:114449.
PMID: 36857911
The antifungal drug itraconazole has been repurposed to anti-angiogenic agent, but the mechanisms of action have been elusive. Here we report that itraconazole disrupts focal adhesion dynamics and cytoskeletal remodeling,...
10.
Wang H, Perera L, Jork N, Zong G, Riley A, Potter B, et al.
Nat Commun
. 2022 Apr;
13(1):2231.
PMID: 35468885
Structural snapshots of protein/ligand complexes are a prerequisite for gaining atomic level insight into enzymatic reaction mechanisms. An important group of enzymes has been deprived of this analytical privilege: members...