Hayden J Selvadurai
Overview
Explore the profile of Hayden J Selvadurai including associated specialties, affiliations and a list of published articles.
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8
Citations
630
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Recent Articles
1.
Desai K, Wanggou S, Luis E, Whetstone H, Yu C, Vanner R, et al.
Nat Commun
. 2025 Feb;
16(1):1092.
PMID: 39904987
Functional cellular heterogeneity in tumours often underlies incomplete response to therapy and relapse. Previously, we demonstrated that the growth of the paediatric brain malignancy, sonic hedgehog subgroup medulloblastoma, is rooted...
2.
Chen X, Momin A, Wanggou S, Wang X, Min H, Dou W, et al.
Neuron
. 2022 Nov;
111(1):30-48.e14.
PMID: 36323321
Major obstacles in brain cancer treatment include the blood-tumor barrier (BTB), which limits the access of most therapeutic agents, and quiescent tumor cells, which resist conventional chemotherapy. Here, we show...
3.
Selvadurai H, Luis E, Desai K, Lan X, Vladoiu M, Whitley O, et al.
Cell Rep
. 2020 Apr;
31(2):107511.
PMID: 32294450
Medulloblastoma (MB) is a neoplasm linked to dysregulated cerebellar development. Previously, we demonstrated that the Sonic Hedgehog (SHH) subgroup grows hierarchically, with Sox2 cells at the apex of tumor progression...
4.
Rajakulendran N, Rowland K, Selvadurai H, Ahmadi M, Park N, Naumenko S, et al.
Genes Dev
. 2019 Mar;
33(9-10):498-510.
PMID: 30842215
Developmental signal transduction pathways act diversely, with context-dependent roles across systems and disease types. Glioblastomas (GBMs), which are the poorest prognosis primary brain cancers, strongly resemble developmental systems, but these...
5.
Lan X, Jorg D, Cavalli F, Richards L, Nguyen L, Vanner R, et al.
Nature
. 2017 Aug;
549(7671):227-232.
PMID: 28854171
Human glioblastomas harbour a subpopulation of glioblastoma stem cells that drive tumorigenesis. However, the origin of intratumoural functional heterogeneity between glioblastoma cells remains poorly understood. Here we study the clonal...
6.
Dolma S, Selvadurai H, Lan X, Lee L, Kushida M, Voisin V, et al.
Cancer Cell
. 2016 Jun;
29(6):859-873.
PMID: 27300435
Glioblastomas (GBM) grow in a rich neurochemical milieu, but the impact of neurochemicals on GBM growth is largely unexplored. We interrogated 680 neurochemical compounds in patient-derived GBM neural stem cells...
7.
Vanner R, Remke M, Gallo M, Selvadurai H, Coutinho F, Lee L, et al.
Cancer Cell
. 2014 Jun;
26(1):33-47.
PMID: 24954133
Functional heterogeneity within tumors presents a significant therapeutic challenge. Here we show that quiescent, therapy-resistant Sox2(+) cells propagate sonic hedgehog subgroup medulloblastoma by a mechanism that mirrors a neurogenic program....
8.
Selvadurai H, Mason J
PLoS One
. 2012 Aug;
7(8):e42572.
PMID: 22880037
Development of the cerebellum proceeds under the precise spatio-temporal control of several key developmental signalling pathways, including the Wnt/β-catenin pathway. We recently reported the activity of Wnt/β-catenin signalling in the...
9.
Selvadurai H, Mason J
PLoS One
. 2011 Aug;
6(8):e23012.
PMID: 21857982
The adult cerebellum is composed of several distinct cell types with well defined developmental origins. However, the molecular mechanisms that govern the generation of these cell types are only partially...