Heather Whetstone
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Explore the profile of Heather Whetstone including associated specialties, affiliations and a list of published articles.
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35
Citations
2055
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Recent Articles
1.
Desai K, Wanggou S, Luis E, Whetstone H, Yu C, Vanner R, et al.
Nat Commun
. 2025 Feb;
16(1):1092.
PMID: 39904987
Functional cellular heterogeneity in tumours often underlies incomplete response to therapy and relapse. Previously, we demonstrated that the growth of the paediatric brain malignancy, sonic hedgehog subgroup medulloblastoma, is rooted...
2.
Ucciferri C, Gower A, Alvarez-Sanchez N, Whetstone H, Ramaglia V, Gommerman J, et al.
J Vis Exp
. 2024 Mar;
(204).
PMID: 38465945
Experimental autoimmune encephalomyelitis (EAE) is a common immune-based model of multiple sclerosis (MS). This disease can be induced in rodents by active immunization with protein components of the myelin sheath...
3.
Almizraq R, Boligan K, Lewis B, Cen S, Whetstone H, Spirig R, et al.
Pharmacology
. 2023 Jan;
108(2):176-187.
PMID: 36696888
Introduction: Neutrophils are a pivotal cell type in the K/BxN mouse model of rheumatoid arthritis and play an essential role in the progression of the arthritis. They are readily activated...
4.
Doroshenko E, Drohomyrecky P, Gower A, Whetstone H, Cahill L, Ganguly M, et al.
Front Immunol
. 2021 Mar;
12:570425.
PMID: 33732230
Peroxisome proliferator-activated receptor (PPAR)-δ is a nuclear receptor that functions to maintain metabolic homeostasis, regulate cell growth, and limit the development of excessive inflammation during immune responses. Previously, we reported...
5.
Sachamitr P, Ho J, Ciamponi F, Ba-Alawi W, Coutinho F, Guilhamon P, et al.
Nat Commun
. 2021 Feb;
12(1):979.
PMID: 33579912
Glioblastoma (GBM) is a deadly cancer in which cancer stem cells (CSCs) sustain tumor growth and contribute to therapeutic resistance. Protein arginine methyltransferase 5 (PRMT5) has recently emerged as a...
6.
Guilhamon P, Chesnelong C, Kushida M, Nikolic A, Singhal D, MacLeod G, et al.
Elife
. 2021 Jan;
10.
PMID: 33427645
Chromatin accessibility discriminates stem from mature cell populations, enabling the identification of primitive stem-like cells in primary tumors, such as glioblastoma (GBM) where self-renewing cells driving cancer progression and recurrence...
7.
Selvadurai H, Luis E, Desai K, Lan X, Vladoiu M, Whitley O, et al.
Cell Rep
. 2020 Apr;
31(2):107511.
PMID: 32294450
Medulloblastoma (MB) is a neoplasm linked to dysregulated cerebellar development. Previously, we demonstrated that the Sonic Hedgehog (SHH) subgroup grows hierarchically, with Sox2 cells at the apex of tumor progression...
8.
Cahill L, Zhang M, Ramaglia V, Whetstone H, Sabbagh M, Yi T, et al.
Proc Natl Acad Sci U S A
. 2019 Oct;
116(45):22710-22720.
PMID: 31641069
Experimental autoimmune encephalomyelitis (EAE) is the most common model of multiple sclerosis (MS). This model has been instrumental in understanding the events that lead to the initiation of central nervous...
9.
Vi L, Baht G, Soderblom E, Whetstone H, Wei Q, Furman B, et al.
Nat Commun
. 2018 Dec;
9(1):5191.
PMID: 30518764
The pace of repair declines with age and, while exposure to a young circulation can rejuvenate fracture repair, the cell types and factors responsible for rejuvenation are unknown. Here we...
10.
Chen X, Wanggou S, Bodalia A, Zhu M, Dong W, Fan J, et al.
Neuron
. 2018 Oct;
100(4):799-815.e7.
PMID: 30344046
Alteration of tissue mechanical properties is a physical hallmark of solid tumors including gliomas. How tumor cells sense and regulate tissue mechanics is largely unknown. Here, we show that mechanosensitive...