Hartmut Osswald
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Explore the profile of Hartmut Osswald including associated specialties, affiliations and a list of published articles.
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50
Citations
1457
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Recent Articles
1.
Grenz A, Bauerle J, Dalton J, Ridyard D, Badulak A, Tak E, et al.
J Clin Invest
. 2017 Jun;
127(6):2438.
PMID: 28569735
No abstract available.
2.
Grenz A, Bauerle J, Dalton J, Ridyard D, Badulak A, Tak E, et al.
J Clin Invest
. 2012 Jan;
122(2):693-710.
PMID: 22269324
A complex biologic network regulates kidney perfusion under physiologic conditions. This system is profoundly perturbed following renal ischemia, a leading cause of acute kidney injury (AKI) - a life-threatening condition...
3.
4.
Osswald H, Schnermann J
Handb Exp Pharmacol
. 2010 Sep;
(200):391-412.
PMID: 20859805
This chapter describes the effects of the natural methylxanthines caffeine and theophylline on kidney function. Theophylline in particular was used traditionally to increase urine out put until more potent diuretics...
5.
Grenz A, Hermes M, Hammel P, Roll J, Osswald H, Kloor D
Cell Physiol Biochem
. 2010 Aug;
26(3):449-56.
PMID: 20798530
Background/aims: Elevated plasma homocysteine (Hcy) levels have been identified as a pathogenic factor causing a variety of pathological changes in different cells and tissues. In vertebrates, Hcy is produced solely...
6.
Huang D, Gao H, Boini K, Osswald H, Nurnberg B, Lang F
Pflugers Arch
. 2010 Mar;
460(1):187-96.
PMID: 20349193
AMP-activated protein kinase (AMPK) is expressed in the apical membrane of cortical thick ascending limb, distal, and collecting tubules as well as macula densa cells of the kidneys. AMPK is...
7.
Vallon V, Osswald H
Handb Exp Pharmacol
. 2009 Jul;
(193):443-70.
PMID: 19639291
The autacoid, adenosine, is present in the normoxic kidney and generated in the cytosol as well as at extracellular sites. The rate of adenosine formation is enhanced when the rate...
8.
Kloor D, Hermes M, Kirschler J, Muller M, Hagen N, Kalbacher H, et al.
Naunyn Schmiedebergs Arch Pharmacol
. 2009 Jun;
380(3):215-22.
PMID: 19547959
S-Adenosylhomocysteine-hydrolase (AdoHcy-hydrolase) catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and homocysteine (Hcy). Since Ado competes with cAMP at the high affinity-binding site of the enzyme, we determined...
9.
Ackermann S, Hiller S, Osswald H, Losle M, Grenz A, Hambrock A
J Biol Chem
. 2008 Dec;
284(8):4905-13.
PMID: 19095654
Apoptosis of pancreatic beta-cells is an important factor in the pathophysiology of diabetes. Previously, we have shown that the "phytoestrogen" resveratrol can induce beta-cell apoptosis dependent on the expression of...
10.
Hermes M, Osswald H, Riehle R, Piesch C, Kloor D
Cell Physiol Biochem
. 2008 Sep;
22(1-4):223-36.
PMID: 18769049
Background/aims: S-Adenosylhomocysteine hydrolase (AdoHcyase) catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy), which is a potent product inhibitor of S-adenosylmethionine (AdoMet)-dependent methyltransferases. While previous studies have shown that AdoHcyase inhibition or...