Harrys K C Jacob
Overview
Explore the profile of Harrys K C Jacob including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
572
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0
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Recent Articles
1.
Paniagua G, Jacob H, Brehey O, Garcia-Alonso S, Lechuga C, Pons T, et al.
Mol Oncol
. 2022 Mar;
16(17):3066-3081.
PMID: 35313064
The kinase suppressor of rat sarcoma (RAS) proteins (KSR1 and KSR2) have long been considered as scaffolding proteins required for optimal mitogen-activated protein kinase (MAPK) pathway signalling. However, recent evidence...
2.
Palathingal Bava E, George J, Tarique M, Iyer S, Sahay P, Gomez Aguilar B, et al.
JCI Insight
. 2021 Nov;
7(2).
PMID: 34847076
Despite decades of research, there is no specific therapy for acute pancreatitis (AP). In the current study, we have evaluated the efficacy of pirfenidone, an antiinflammatory and antifibrotic agent that...
3.
Giri B, Sharma P, Jain T, Ferrantella A, Vaish U, Mehra S, et al.
Oncoimmunology
. 2021 Sep;
10(1):1976952.
PMID: 34552825
Heat shock protein 70 (Hsp70), a protein chaperone, is known to promote cell survival and tumor progression. However, its role in the tumor microenvironment (TME) is largely unknown. We specifically...
4.
Giri B, Ferrantella A, Sharma P, Jain T, Jacob H, Modi S, et al.
J Gastrointest Surg
. 2020 Jun;
25(5):1271-1279.
PMID: 32542554
Background: Even after surgical resection, most patients with localized pancreatic ductal adenocarcinoma (PDAC) succumb to disease recurrence. Current animal models do not recapitulate this pattern of disease recurrence. Our goal...
5.
Jacob H, Banerjee S
Gastroenterology
. 2019 Aug;
157(4):929-932.
PMID: 31400367
No abstract available.
6.
Blasco M, Navas C, Martin-Serrano G, Grana-Castro O, Lechuga C, Martin-Diaz L, et al.
Cancer Cell
. 2019 Apr;
35(4):573-587.e6.
PMID: 30975481
Five-year survival for pancreatic ductal adenocarcinoma (PDAC) patients remains below 7% due to the lack of effective treatments. Here, we report that combined ablation of EGFR and c-RAF expression results...
7.
Simon-Carrasco L, Grana O, Salmon M, Jacob H, Gutierrez A, Jimenez G, et al.
Genes Dev
. 2017 Aug;
31(14):1456-1468.
PMID: 28827401
CIC (also known as Capicua) is a transcriptional repressor negatively regulated by RAS/MAPK signaling. Whereas the functions of Cic have been well characterized in , little is known about its...
8.
Lechuga C, Simon-Carrasco L, Jacob H, Drosten M
Methods Mol Biol
. 2016 Dec;
1487:269-276.
PMID: 27924574
Signaling transmitted by the Ras family of small GTPases (H-, N-, and K-Ras) is essential for proliferation of mouse embryonic fibroblasts (MEFs). However, constitutive activation of the downstream Raf/Mek/Erk pathway...
9.
Drosten M, Simon-Carrasco L, Hernandez-Porras I, Lechuga C, Blasco M, Jacob H, et al.
Cancer Res
. 2016 Nov;
77(3):707-718.
PMID: 27872088
Genetic studies in mice have provided evidence that H-Ras and K-Ras proteins are bioequivalent. However, human tumors display marked differences in the association of RAS oncogenes with tumor type. Thus,...
10.
Marimuthu A, Jacob H, Jakharia A, Subbannayya Y, Keerthikumar S, Kashyap M, et al.
J Proteomics Bioinform
. 2016 Apr;
4(4):74-82.
PMID: 27030788
Gastric cancer is the second leading cause of cancer death worldwide, both in men and women. A genomewide gene expression analysis was carried out to identify differentially expressed genes in...