Harmen J Bussemaker
Overview
Explore the profile of Harmen J Bussemaker including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
76
Citations
4934
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Gagoski D, Rube T, Rube H, Rastogi C, Melo L, Melo L, et al.
bioRxiv
. 2025 Jan;
PMID: 39764007
Short linear peptide motifs play important roles in cell signaling. They can act as modification sites for enzymes and as recognition sites for peptide binding domains. SH2 domains bind specifically...
2.
Li X, Melo L, Bussemaker H
Genome Biol
. 2024 Nov;
25(1):284.
PMID: 39482734
Background: Transcription factors (TFs) bind to DNA in a highly sequence-specific manner. This specificity manifests itself in vivo as differences in TF occupancy between the two alleles at heterozygous loci....
3.
Liu S, Gomez-Alcala P, Leemans C, Glassford W, Mann R, Bussemaker H
bioRxiv
. 2024 Feb;
PMID: 38352411
Sequence-specific interactions of transcription factors (TFs) with genomic DNA underlie many cellular processes. High-throughput binding assays coupled with computational analysis have made it possible to accurately define such sequence recognition...
4.
Li X, Melo L, Bussemaker H
bioRxiv
. 2024 Jan;
PMID: 38168434
Transcription factors (TFs) bind to DNA in a highly sequence-specific manner. This specificity can manifest itself at heterozygous loci as a difference in TF occupancy between the two alleles. When...
5.
Li X, Lappalainen T, Bussemaker H
Cell Genom
. 2023 Sep;
3(9):100382.
PMID: 37719147
Genetic variants affecting gene expression levels in humans have been mapped in the Genotype-Tissue Expression (GTEx) project. -acting variants impacting many genes simultaneously through a shared transcription factor (TF) are...
6.
Trauernicht M, Rastogi C, Manzo S, Bussemaker H, van Steensel B
Nucleic Acids Res
. 2023 Aug;
51(18):9690-9702.
PMID: 37650627
TP53 is a transcription factor that controls multiple cellular processes, including cell cycle arrest, DNA repair and apoptosis. The relation between TP53 binding site architecture and transcriptional output is still...
7.
Nora E, Aerts S, Wittkopp P, Bussemaker H, Bulyk M, Sinha S, et al.
Cell Syst
. 2023 Apr;
14(4):247-251.
PMID: 37080160
What new questions can we ask about transcriptional regulation given recent developments in large-scale approaches?
8.
FitzPatrick V, Leemans C, van Arensbergen J, van Steensel B, Bussemaker H
Nucleic Acids Res
. 2023 Apr;
51(11):5499-5511.
PMID: 37013986
Classic promoter mutagenesis strategies can be used to study how proximal promoter regions regulate the expression of particular genes of interest. This is a laborious process, in which the smallest...
9.
Feng S, Rastogi C, Loker R, Glassford W, Rube H, Bussemaker H, et al.
Nat Commun
. 2022 Jul;
13(1):3808.
PMID: 35778382
In eukaryotes, members of transcription factor families often exhibit similar DNA binding properties in vitro, yet orchestrate paralog-specific gene regulatory networks in vivo. The serially homologous first (T1) and third...
10.
Rube H, Rastogi C, Feng S, Kribelbauer J, Li A, Becerra B, et al.
Nat Biotechnol
. 2022 May;
40(10):1520-1527.
PMID: 35606422
Protein-ligand interactions are increasingly profiled at high throughput using affinity selection and massively parallel sequencing. However, these assays do not provide the biophysical parameters that most rigorously quantify molecular interactions....