Hans Zempel
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Explore the profile of Hans Zempel including associated specialties, affiliations and a list of published articles.
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Articles
36
Citations
1128
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Recent Articles
1.
Buchholz S, Kabbani M, Bell-Simons M, Kluge L, Cagmak C, Klimek J, et al.
Alzheimers Dement
. 2025 Feb;
:e14403.
PMID: 40019008
Introduction: Human tau protein, composed of six brain-specific isoforms, is a major driver of Alzheimer's disease (AD). The role of its isoforms however remains unclear and human AD models are...
2.
Mantey I, Langerscheidt F, Cakmak Durmaz C, Baba N, Burghardt K, Karakaya M, et al.
Genes (Basel)
. 2025 Feb;
16(2).
PMID: 40004527
Background: The nuclear-encoded enzyme polymerase gamma (Pol-γ) is crucial in the replication of the mitochondrial genome (mtDNA), which in turn is vital for mitochondria and hence numerous metabolic processes and...
3.
Breuer H, Bell-Simons M, Zempel H
Open Life Sci
. 2025 Jan;
19(1):20221010.
PMID: 39759106
Cell polarity is crucial in neurons, characterized by distinct axonal and dendritic structures. Neurons generally have one long axon and multiple shorter dendrites, marked by specific microtubule (MT)-associated proteins, e.g.,...
4.
Haag N, Bremer J, Zempel H
Signal Transduct Target Ther
. 2024 Sep;
9(1):252.
PMID: 39313493
No abstract available.
5.
Adam D, Langerscheidt F, Zempel H
Neural Regen Res
. 2024 Jul;
20(5):1407-1408.
PMID: 39075906
No abstract available.
6.
Kabbani M, Kohler C, Zempel H
Neural Regen Res
. 2024 Jun;
20(8):2348-2360.
PMID: 38934386
JOURNAL/nrgr/04.03/01300535-202508000-00025/figure1/v/2024-09-30T120553Z/r/image-tiff TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the axon. TAU is missorted and aggregated in an array of diseases known as tauopathies. Microtubules are...
7.
Cakmak C, Zempel H
Med Genet
. 2024 Jun;
33(3):245-249.
PMID: 38835703
Neurogenetic diseases represent a broad group of diseases with variable genetic causes and clinical manifestations. Among these, polymerase-gamma (POLG)-spectrum disorders are relatively frequent with an estimated disease frequency of ∼1:10.000....
8.
Buchholz S, Zempel H
Alzheimers Dement
. 2024 Apr;
20(5):3606-3628.
PMID: 38556838
Introduction: Alternative splicing of the human MAPT gene generates six brain-specific TAU isoforms. Imbalances in the TAU isoform ratio can lead to neurodegenerative diseases, underscoring the need for precise control...
9.
Langerscheidt F, Wied T, Kabbani M, van Eimeren T, Wunderlich G, Zempel H
J Neurol
. 2024 Mar;
271(6):2992-3018.
PMID: 38554150
Tauopathies are a heterogeneous group of neurologic diseases characterized by pathological axodendritic distribution, ectopic expression, and/or phosphorylation and aggregation of the microtubule-associated protein TAU, encoded by the gene MAPT. Neuronal...
10.
Allroggen N, Breuer H, Bachmann S, Bell M, Zempel H
Methods Mol Biol
. 2024 Mar;
2754:561-580.
PMID: 38512690
The study of microtubule (MT) dynamics is essential for the understanding of cellular transport, cell polarity, axon formation, and other neurodevelopmental mechanisms. All these processes rely on the constant transition...