Hanna Liao
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Explore the profile of Hanna Liao including associated specialties, affiliations and a list of published articles.
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10
Citations
197
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Recent Articles
1.
Choi J, Chen W, Liao H, Li X, Shendure J
Elife
. 2025 Feb;
13.
PMID: 39937081
One of the goals of synthetic biology is to enable the design of arbitrary molecular circuits with programmable inputs and outputs. Such circuits bridge the properties of electronic and natural...
2.
Liao H, Kottapalli S, Huang Y, Chaw M, Gehring J, Waltner O, et al.
bioRxiv
. 2024 Aug;
PMID: 39149271
Spatial genomic technologies include imaging- and sequencing-based methods (1-3). An emerging subcategory of sequencing-based methods relies on a surface coated with coordinate-associated DNA barcodes, which are leveraged to tag endogenous...
3.
Paquette A, Ahuna K, Hwang Y, Pearl J, Liao H, Shannon P, et al.
Sci Adv
. 2024 Jun;
10(26):eadf3411.
PMID: 38941464
Gene regulation is essential to placental function and fetal development. We built a genome-scale transcriptional regulatory network (TRN) of the human placenta using digital genomic footprinting and transcriptomic data. We...
4.
Liao H, Choi J, Shendure J
Nat Protoc
. 2024 Jun;
19(10):2833-2862.
PMID: 38844553
Recording molecular information to genomic DNA is a powerful means of investigating topics ranging from multicellular development to cancer evolution. With molecular recording based on genome editing, events such as...
5.
Choi J, Chen W, Liao H, Li X, Shendure J
bioRxiv
. 2023 Aug;
PMID: 37645782
One of the goals of synthetic biology is to enable the design of arbitrary molecular circuits with programmable inputs and outputs. Such circuits bridge the properties of electronic and natural...
6.
Doebley A, Ko M, Liao H, Cruikshank A, Santos K, Kikawa C, et al.
Nat Commun
. 2023 Jan;
14(1):403.
PMID: 36697405
No abstract available.
7.
Doebley A, Ko M, Liao H, Cruikshank A, Santos K, Kikawa C, et al.
Nat Commun
. 2022 Dec;
13(1):7475.
PMID: 36463275
Cell-free DNA (cfDNA) has the potential to inform tumor subtype classification and help guide clinical precision oncology. Here we develop Griffin, a framework for profiling nucleosome protection and accessibility from...
8.
Tresenrider A, Morse K, Jorgensen V, Chia M, Liao H, van Werven F, et al.
Mol Cell
. 2021 Apr;
81(10):2231-2245.e11.
PMID: 33826921
Long undecoded transcript isoforms (LUTIs) represent a class of non-canonical mRNAs that downregulate gene expression through the combined act of transcriptional and translational repression. While single gene studies revealed important...
9.
Chen Z, Kibler R, Hunt A, Busch F, Pearl J, Jia M, et al.
Science
. 2020 Apr;
368(6486):78-84.
PMID: 32241946
The design of modular protein logic for regulating protein function at the posttranscriptional level is a challenge for synthetic biology. Here, we describe the design of two-input AND, OR, NAND,...
10.
Chen J, Liao A, Powers E, Liao H, Kohlstaedt L, Evans R, et al.
Genes Dev
. 2020 Jan;
34(3-4):209-225.
PMID: 31919192
The kinetochore complex is a conserved machinery that connects chromosomes to spindle microtubules. During meiosis, the kinetochore is restructured to accommodate a specialized chromosome segregation pattern. In budding yeast, meiotic...