Barbro Kahl-Knutson
Overview
Explore the profile of Barbro Kahl-Knutson including associated specialties, affiliations and a list of published articles.
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12
Citations
174
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Recent Articles
1.
Peterson K, Nilsson U, Gravelle L, Holyer I, Jansson K, Kahl-Knutson B, et al.
J Med Chem
. 2024 Dec;
67(24):21905-21915.
PMID: 39668131
The interest in galectin-3 as a drug target in the cancer and fibrosis space has grown during the past few years with several new classes of compounds being developed. The...
2.
Comeglio P, Guarnieri G, Filippi S, Cellai I, Acciai G, Holyer I, et al.
Front Pharmacol
. 2024 Aug;
15:1430109.
PMID: 39144627
Introduction: Galectin-3 is a pro-fibrotic β-galactoside binding lectin highly expressed in fibrotic liver and implicated in hepatic fibrosis. Selvigaltin (previously known as GB1211) is a novel orally active galectin-3 small...
3.
Kim H, Kretz L, Ronin C, Starck C, Roper J, Kahl-Knutson B, et al.
Int J Mol Sci
. 2024 Jun;
25(12).
PMID: 38928409
The beta-galactoside-binding mammalian lectin galectin-1 can bind, via its carbohydrate recognition domain (CRD), to various cell surface glycoproteins and has been implicated in a range of cancers. As a consequence...
4.
Zetterberg F, Peterson K, Nilsson U, Andreasson Dahlgren K, Diehl C, Holyer I, et al.
J Med Chem
. 2024 May;
67(11):9374-9388.
PMID: 38804039
We have previously described a new series of selective and orally available galectin-1 inhibitors resulting in the thiazole-containing glycomimetic GB1490. Here, we show that the introduction of polar substituents to...
5.
Zetterberg F, Diehl C, Hakansson M, Kahl-Knutson B, Leffler H, Nilsson U, et al.
J Med Chem
. 2023 Dec;
66(24):16980-16990.
PMID: 38059452
A new series of orally available α-d-galactopyranosides with high affinity and specificity toward galectin-1 have been discovered. High affinity and specificity were achieved by changing six-membered aryl-triazolyl substituents in a...
6.
Kim H, Weidner N, Ronin C, Klein E, Roper J, Kahl-Knutson B, et al.
SLAS Discov
. 2023 Mar;
28(5):233-239.
PMID: 36990319
Galectin-3 is a beta-galactoside-binding mammalian lectin that is one of a 15-member galectin family that can bind several cell surface glycoproteins via its carbohydrate recognition domain (CRD). As a result,...
7.
Zetterberg F, MacKinnon A, Brimert T, Gravelle L, Johnsson R, Kahl-Knutson B, et al.
J Med Chem
. 2022 Sep;
65(19):12626-12638.
PMID: 36154172
Galectin-3 is a carbohydrate-binding protein central to regulating mechanisms of diseases such as fibrosis, cancer, metabolic, inflammatory, and heart disease. We recently found a high affinity (nM) thiodigalactoside GB0139 which...
8.
Sun L, Konstantinidi A, Ye Z, Nason R, Zhang Y, Bull C, et al.
J Biol Chem
. 2021 Dec;
298(2):101382.
PMID: 34954141
The human genome contains at least 35 genes that encode Golgi sulfotransferases that function in the secretory pathway, where they are involved in decorating glycosaminoglycans, glycolipids, and glycoproteins with sulfate...
9.
Stegmayr J, Zetterberg F, Carlsson M, Huang X, Sharma G, Kahl-Knutson B, et al.
Sci Rep
. 2019 Feb;
9(1):2186.
PMID: 30778105
Galectin-3 is a carbohydrate binding protein which has important roles in cancer and immunity. Potent galectin-3 inhibitors have been synthesized, for experimental purposes and potential clinical use. As galectin-3 is...
10.
Stegmayr J, Lepur A, Kahl-Knutson B, Aguilar-Moncayo M, Klyosov A, Field R, et al.
J Biol Chem
. 2016 Apr;
291(25):13318-34.
PMID: 27129206
Some complex plant-derived polysaccharides, such as modified citrus pectins and galactomannans, have been shown to have promising anti-inflammatory and anti-cancer effects. Most reports propose or claim that these effects are...