H Ziffer
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Explore the profile of H Ziffer including associated specialties, affiliations and a list of published articles.
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53
Citations
242
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Recent Articles
1.
Simpson J, Torok D, Worman R, Quearry B, Markey S, Ziffer H
J Am Soc Mass Spectrom
. 2013 Nov;
6(2):148-51.
PMID: 24222077
Anthraquinone-2-carbonyl chloride has been utilized as a derivatization reagent for alcohols to impart electron affinity and aid in transport via a particle beam liquid chromatography-mass spectrometry (LC/MS) interface. In addition,...
2.
Sherman W, Sprecace G, Pomper S, Lemlich A, Ziffer H
Trans Am Clin Climatol Assoc
. 2011 Mar;
75:144-52.
PMID: 21408642
No abstract available.
3.
Ma J, Katz E, Kyle D, Ziffer H
J Med Chem
. 2000 Nov;
43(22):4228-32.
PMID: 11063619
Two series of 10-substituted deoxoartemisinin derivatives have been synthesized. The first employed the reaction of dihydroartemisinin acetate with several silyl enol ethers in the presence of titanium tetrachloride. The second...
4.
Ma J, Weiss E, Kyle D, Ziffer H
Bioorg Med Chem Lett
. 2000 Jul;
10(14):1601-3.
PMID: 10915061
A series of 14-substituted-artemisinin and 9-epiartemisinin derivatives was prepared by a titanium-tetrachloride catalyzed addition of trimethylsilyl enol ethers to artemisitene. Several compounds were four to seven times more active than...
5.
Mekonnen B, Weiss E, Katz E, Ma J, Ziffer H, Kyle D
Bioorg Med Chem
. 2000 Jul;
8(5):1111-6.
PMID: 10882021
A series of N-substituted 11-azaartemisinins were prepared in high yield employing base-catalyzed additions to an amide nitrogen of olefins and terminal acetylenes conjugated with electron withdrawing groups (EWGs). When the...
6.
Katz E, Ma J, Kyle D, Ziffer H
Bioorg Med Chem Lett
. 1999 Nov;
9(20):2969-72.
PMID: 10571157
Several N-substituted 11-azaartemisinins were prepared from 11-azaartemisinin in high yield by the DMAP catalyzed addition of terminal acetylenes conjugated with electron-withdrawing groups. Their antimalarial activities against two drug-resistant strains of...
7.
Ziffer H, Highet R, Klayman D
Fortschr Chem Org Naturst
. 1997 Jan;
72:121-214.
PMID: 9369092
No abstract available.
8.
Kamchonwongpaisan S, McKeever P, Hossler P, Ziffer H, Meshnick S
Am J Trop Med Hyg
. 1997 Jan;
56(1):7-12.
PMID: 9063352
Despite the wide use of artermisinin and its derivatives, concerns have been raised about their potential neurotoxicity. Accordingly, studies were undertaken on rats treated with high doses of arteether and...
9.
Torok D, Ziffer H, Meshnick S, Pan X, Ager A
J Med Chem
. 1995 Dec;
38(26):5045-50.
PMID: 8544181
A two-step reaction sequence between artemisinin and methanolic ammonia followed by treatment with Amberlyst 15 yielded 11-azaartemisinin in 65% yield. Substituting a variety of primary alkyl- and heteroaromatic amines for...
10.
Pu Y, Torok D, Ziffer H, Pan X, Meshnick S
J Med Chem
. 1995 Sep;
38(20):4120-4.
PMID: 7562948
The carbonyl groups in several artemisinin derivatives were converted into geminal difluorinated compounds on treatment with diethylaminosulfur trifluoride. A number of other mono- and polyfluorinated artemisinin derivatives were prepared. Their...