Frank C P Holstege
Overview
Explore the profile of Frank C P Holstege including associated specialties, affiliations and a list of published articles.
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Articles
121
Citations
5019
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Recent Articles
1.
van Belzen I, van Tuil M, Badloe S, Janse A, Verwiel E, Santoso M, et al.
Cell Genom
. 2024 Oct;
4(11):100675.
PMID: 39406233
In pediatric cancer, structural variants (SVs) and copy-number alterations contribute to cancer initiation as well as progression, thereby aiding diagnosis and treatment stratification. Although suggested to be of importance, the...
2.
de Kanter J, Steemers A, Gonzalez D, van Ineveld R, Blijleven C, Groenen N, et al.
Hemasphere
. 2024 Sep;
8(9):e149.
PMID: 39233904
Pediatric classic Hodgkin lymphoma (cHL) patients have a high survival rate but suffer from severe long-term side effects induced by chemo- and radiotherapy. cHL tumors are characterized by the low...
3.
Hendriks D, Pagliaro A, Andreatta F, Ma Z, van Giessen J, Massalini S, et al.
Cell
. 2024 Jan;
187(3):712-732.e38.
PMID: 38194967
Human brain development involves an orchestrated, massive neural progenitor expansion while a multi-cellular tissue architecture is established. Continuously expanding organoids can be grown directly from multiple somatic tissues, yet to...
4.
Wienke J, Visser L, Kholosy W, Keller K, Barisa M, Poon E, et al.
Cancer Cell
. 2024 Jan;
42(2):283-300.e8.
PMID: 38181797
Pediatric patients with high-risk neuroblastoma have poor survival rates and urgently need more effective treatment options with less side effects. Since novel and improved immunotherapies may fill this need, we...
5.
Visser L, Bleijs M, Margaritis T, van de Wetering M, Holstege F, Clevers H
Cancer Res Commun
. 2023 Oct;
3(10):2158-2169.
PMID: 37823774
Significance: This study is the first presenting a detailed analysis of the Ewing sarcoma microenvironment using single-cell RNA sequencing. We provide novel insight into the functional state of immune cells...
6.
Heim C, Moser L, Kreyenberg H, Bonig H, Tonn T, Wels W, et al.
Front Immunol
. 2023 Sep;
14:1228894.
PMID: 37662907
Introduction: Metastatic rhabdomyosarcoma (RMS) is a challenging tumor entity that evades conventional treatments and endogenous antitumor immune responses, highlighting the need for novel therapeutic strategies. Applying chimeric antigen receptor (CAR)...
7.
van Belzen I, Cai C, van Tuil M, Badloe S, Strengman E, Janse A, et al.
BMC Cancer
. 2023 Jul;
23(1):618.
PMID: 37400763
Background: Gene fusions are important cancer drivers in pediatric cancer and their accurate detection is essential for diagnosis and treatment. Clinical decision-making requires high confidence and precision of detection. Recent...
8.
DeMartino J, Meister M, Visser L, Brok M, Groot Koerkamp M, Wezenaar A, et al.
Nat Commun
. 2023 May;
14(1):3074.
PMID: 37244912
Paediatric rhabdomyosarcoma (RMS) is a soft tissue malignancy of mesenchymal origin that is thought to arise as a consequence of derailed myogenic differentiation. Despite intensive treatment regimens, the prognosis for...
9.
van Zogchel L, Lak N, Gelineau N, Sergeeva I, Stelloo E, Swennenhuis J, et al.
Front Oncol
. 2023 May;
13:1124737.
PMID: 37152023
Background: Liquid biopsies combine minimally invasive sample collection with sensitive detection of residual disease. Pediatric malignancies harbor tumor-driving copy number alterations or fusion genes, rather than recurrent point mutations. These...
10.
Madsen M, Broekema M, Madsen M, Koppen A, Borgman A, Grawe C, et al.
Nat Commun
. 2022 Nov;
13(1):7090.
PMID: 36402763
Peroxisome proliferator-activated receptor γ (PPARγ) is the master regulator of adipocyte differentiation, and mutations that interfere with its function cause lipodystrophy. PPARγ is a highly modular protein, and structural studies...