H S Kruth
Overview
Explore the profile of H S Kruth including associated specialties, affiliations and a list of published articles.
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Articles
71
Citations
1541
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Recent Articles
1.
Kruth H
Curr Mol Med
. 2002 Mar;
1(6):633-53.
PMID: 11899253
Progressive accumulation of cholesterol in the arterial wall causes atherosclerosis, the pathologic process underlying most heart attacks and strokes. Low density lipoprotein (LDL), the major carrier of blood cholesterol, has...
2.
Kruth H, Ifrim I, Chang J, Addadi L, Zhang W
J Lipid Res
. 2001 Aug;
42(9):1492-500.
PMID: 11518770
The hypothesis of lipid domains in cellular plasma membranes is well established. However, direct visualization of the domains has been difficult. Here we report direct visualization of plasma membrane cholesterol...
3.
Kruth H
Front Biosci
. 2001 Mar;
6:D429-55.
PMID: 11229875
Focal buildup of cholesterol in arteries is the process that produces atherosclerotic plaques, the cause of most coronary artery disease and strokes. Monocyte-derived macrophages are central cells that accumulate this...
4.
Curcio C, Millican C, Bailey T, Kruth H
Invest Ophthalmol Vis Sci
. 2001 Jan;
42(1):265-74.
PMID: 11133878
Purpose: To determine the cholesterol composition of normal human Bruch's membrane and choroid as a function of age and retinal location. Methods: Human eyes with grossly normal maculas were preserved...
5.
Milam A, Curcio C, Cideciyan A, Saxena S, John S, Kruth H, et al.
Ophthalmology
. 2000 Nov;
107(12):2256-66.
PMID: 11097607
Purpose: To clarify the pathogenesis of late-onset retinal degeneration (L-ORD), an autosomal dominant disorder characterized by thick deposits of lipid-rich material between the retinal pigment epithelium (RPE) and Bruch's membrane....
6.
Zhang W, Ishii I, Kruth H
J Biol Chem
. 2000 Aug;
275(42):33176-83.
PMID: 10942782
Evidence suggests that aggregated low density lipoprotein (AgLDL) accumulates in atherosclerotic lesions. Previously, we showed that AgLDL induces and enters surface-connected compartments (SCC) in human monocyte-derived macrophages by a process...
7.
Kruth H, Chang J, Ifrim I, Zhang W
Eur J Cell Biol
. 1999 Apr;
78(2):91-9.
PMID: 10099931
Previously, we described a unique macrophage endocytosis pathway in which aggregated low density lipoproteins and microcrystalline cholesterol induce and enter a labyrinth of membrane-bound compartments that remain connected to the...
8.
Kruth H, Zhang W, Skarlatos S, Chao F
J Biol Chem
. 1999 Mar;
274(11):7495-500.
PMID: 10066816
Much of the cholesterol that accumulates in atherosclerotic plaques is found within monocyte-macrophages transforming these cells into "foam cells." Native low density lipoprotein (LDL) does not cause foam cell formation....
9.
Zhang W, Gaynor P, Kruth H
J Biol Chem
. 1998 Feb;
272(50):31700-6.
PMID: 9395512
Aggregation of low density lipoprotein (LDL) stimulates its uptake by macrophages. We have now shown by electron microscopic and chemical experiments that aggregated LDL (produced by vortexing (VxLDL) or treatment...
10.
Kruth H
Curr Opin Lipidol
. 1997 Oct;
8(5):246-52.
PMID: 9335947
Recent findings have helped to explain the fate of cholesterol entering the arterial wall. LDL can undergo both fusion and aggregation. These changes may cause increased retention of LDL in...