H Robson MacDonald
Overview
Explore the profile of H Robson MacDonald including associated specialties, affiliations and a list of published articles.
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73
Citations
5573
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Recent Articles
1.
Chennupati V, Veiga D, Maslowski K, Andina N, Tardivel A, Yu E, et al.
J Clin Invest
. 2018 Feb;
128(4):1597-1614.
PMID: 29408805
Ribosomal proteins (RP) regulate specific gene expression by selectively translating subsets of mRNAs. Indeed, in Diamond-Blackfan anemia and 5q- syndrome, mutations in RP genes lead to a specific defect in...
2.
Souilhol C, Lendinez J, Rybtsov S, Murphy F, Wilson H, Hills D, et al.
Blood
. 2016 Jul;
128(12):1567-77.
PMID: 27421959
The first definitive hematopoietic stem cells (dHSCs) in the mouse emerge in the dorsal aorta of the embryonic day (E) 10.5 to 11 aorta-gonad-mesonephros (AGM) region. Notch signaling is essential...
3.
Chennupati V, Koch U, Coutaz M, Scarpellino L, Tacchini-Cottier F, Luther S, et al.
J Immunol
. 2016 Jun;
197(3):771-82.
PMID: 27324132
Although Notch signaling plays important roles in lineage commitment and differentiation of multiple cell types including conventional T cells, nothing is currently known concerning Notch function in innate-like T cells....
4.
Preston G, Sinclair L, Kaskar A, Hukelmann J, Navarro M, Ferrero I, et al.
EMBO J
. 2015 Jul;
34(15):2008-24.
PMID: 26136212
Myc controls the metabolic reprogramming that supports effector T cell differentiation. The expression of Myc is regulated by the T cell antigen receptor (TCR) and pro-inflammatory cytokines such as interleukin-2...
5.
Ludigs K, Seguin-Estevez Q, Lemeille S, Ferrero I, Rota G, Chelbi S, et al.
PLoS Genet
. 2015 Mar;
11(3):e1005088.
PMID: 25811463
MHC class II (MHCII) genes are transactivated by the NOD-like receptor (NLR) family member CIITA, which is recruited to SXY enhancers of MHCII promoters via a DNA-binding "enhanceosome" complex. NLRC5,...
6.
Fasnacht N, Huang H, Koch U, Favre S, Auderset F, Chai Q, et al.
J Exp Med
. 2014 Oct;
211(11):2265-79.
PMID: 25311507
Fibroblast-like cells of secondary lymphoid organs (SLO) are important for tissue architecture. In addition, they regulate lymphocyte compartmentalization through the secretion of chemokines, and participate in the orchestration of appropriate...
7.
Jiang W, Wang X, Zeng B, Liu L, Tardivel A, Wei H, et al.
J Exp Med
. 2013 Sep;
210(11):2465-76.
PMID: 24062413
NOD2 functions as an intracellular sensor for microbial pathogen and plays an important role in epithelial defense. The loss-of-function mutation of NOD2 is strongly associated with human Crohn's disease (CD)....
8.
Auderset F, Schuster S, Fasnacht N, Coutaz M, Charmoy M, Koch U, et al.
J Immunol
. 2013 Aug;
191(5):2344-50.
PMID: 23918982
Follicular helper T (TFH) cells are specialized in providing help for B cell differentiation and Ab secretion. Several positive and negative regulators of TFH cell differentiation have been described but...
9.
Fiorini E, Ferrero I, Poisson C, Scarpellino L, Luther S, MacDonald H
Genesis
. 2013 Jul;
51(10):717-24.
PMID: 23832856
The thymus is the site of T cell development. Several stromal and hematopoietic cell types are necessary for the proper function of thymic selection and eventually peripheral immunity. Thymic epithelial...
10.
Radtke F, MacDonald H, Tacchini-Cottier F
Nat Rev Immunol
. 2013 May;
13(6):427-37.
PMID: 23665520
Coordinated function of the innate and adaptive arms of the immune system in vertebrates is essential to promote protective immunity and to avoid immunopathology. The Notch signalling pathway, which was...