Emma Fiorini
Overview
Explore the profile of Emma Fiorini including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
598
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0
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Recent Articles
1.
Overk C, Fiorini E, Babolin C, Vukicevic M, Morici C, Madani R, et al.
Front Neurosci
. 2023 Jul;
17:1202208.
PMID: 37449271
Introduction: People with DS are highly predisposed to Alzheimer's disease (AD) and demonstrate very similar clinical and pathological features. Ts65Dn mice are widely used and serve as the best-characterized animal...
2.
Njavro J, Vukicevic M, Fiorini E, Dinkel L, Muller S, Berghofer A, et al.
Cells
. 2023 Jan;
12(1).
PMID: 36611872
Amyloid-β (Aβ) deposition is an initiating factor in Alzheimer's disease (AD). Microglia are the brain immune cells that surround and phagocytose Aβ plaques, but their phagocytic capacity declines in AD....
3.
Fiorini E, Ferrero I, Poisson C, Scarpellino L, Luther S, MacDonald H
Genesis
. 2013 Jul;
51(10):717-24.
PMID: 23832856
The thymus is the site of T cell development. Several stromal and hematopoietic cell types are necessary for the proper function of thymic selection and eventually peripheral immunity. Thymic epithelial...
4.
Lee S, Maeda M, Ishikawa Y, Li S, Wilson A, Jubb A, et al.
Blood
. 2012 Nov;
121(6):918-29.
PMID: 23134786
Hematopoietic stem cells (HSCs) are the most primitive cells in the hematopoietic system and are under tight regulation for self-renewal and differentiation. Notch signals are essential for the emergence of...
5.
Basak O, Giachino C, Fiorini E, MacDonald H, Taylor V
J Neurosci
. 2012 Apr;
32(16):5654-66.
PMID: 22514327
The adult mammalian forebrain contains neural stem/progenitor cells (NSCs) that generate neurons throughout life. As in other somatic stem cell systems, NSCs are proposed to be predominantly quiescent and proliferate...
6.
Fiorini E, Merck E, Wilson A, Ferrero I, Jiang W, Koch U, et al.
J Immunol
. 2009 Nov;
183(11):7212-22.
PMID: 19915064
It is well established that Notch signaling plays a critical role at multiple stages of T cell development and activation. However, detailed analysis of the cellular and molecular events associated...
7.
Fiorini E, Ferrero I, Merck E, Favre S, Pierres M, Luther S, et al.
J Immunol
. 2008 Dec;
181(12):8199-203.
PMID: 19050235
Interactions between Notch1 receptors on lymphoid progenitors and Delta-like 4 (DL4) ligands on cortical thymic epithelial cells (cTEC) are essential for T cell lineage commitment, expansion, and maturation in the...
8.
Koch U, Fiorini E, Benedito R, Besseyrias V, Schuster-Gossler K, Pierres M, et al.
J Exp Med
. 2008 Oct;
205(11):2515-23.
PMID: 18824585
Thymic T cell lineage commitment is dependent on Notch1 (N1) receptor-mediated signaling. Although the physiological ligands that interact with N1 expressed on thymic precursors are currently unknown, in vitro culture...
9.
Ferrero I, Grosjean F, Fiorini E, MacDonald H
Eur J Immunol
. 2007 Oct;
37(11):3220-8.
PMID: 17918204
Although it is well established that early expression of TCRbeta transgenes in the thymus leads to efficient inhibition of both endogenous TCRbeta and TCRgamma rearrangement (also known as allelic and...
10.
Kelly A, Finlay D, Hinton H, Clarke R, Fiorini E, Radtke F, et al.
EMBO J
. 2007 Jun;
26(14):3441-50.
PMID: 17599070
Phosphoinositide-dependent kinase l (PDK1) phosphorylates and activates multiple AGC serine kinases, including protein kinase B (PKB), p70Ribosomal S6 kinase (S6K) and p90Ribosomal S6 kinase (RSK). PDK1 is required for thymocyte...