H L Ploegh
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Explore the profile of H L Ploegh including associated specialties, affiliations and a list of published articles.
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186
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7960
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Recent Articles
1.
Walters B, Campbell S, Chen P, Taylor A, Schroeder D, Dobrunz L, et al.
Mol Cell Neurosci
. 2008 Sep;
39(4):539-48.
PMID: 18771733
The ubiquitin proteasome pathway has been implicated in the pathogenesis of many neurodegenerative diseases, and alterations in two different deubiquitinating enzymes, Uch-L1 and Usp14, result in neurological phenotypes in mice....
2.
Ploegh H
Curr Protoc Protein Sci
. 2008 Apr;
Chapter 10:Unit 10.2.
PMID: 18429095
This unit describes isoelectric focusing (IEF) of polypeptides in urea-containing polyacrylamide slab gels as a result of a pH gradient created by ampholytes (small charged organic molecules) in the gel...
3.
Misaghi S, Korbel G, Kessler B, Spooner E, Ploegh H
Cell Death Differ
. 2005 Jul;
13(1):163-5.
PMID: 16003388
No abstract available.
4.
DOrazio S, Halme D, Ploegh H, Starnbach M
J Immunol
. 2003 Jun;
171(1):291-8.
PMID: 12817010
CD8(+) T cells are required for protective immunity against intracellular pathogens such as Listeria monocytogenes. In this study, we used class Ia MHC-deficient mice, which have a severe reduction in...
5.
Hudson A, Howley P, Ploegh H
J Virol
. 2001 Nov;
75(24):12347-58.
PMID: 11711625
All members of the herpesvirus family persist in their host throughout life. In doing so, herpesviruses exploit a surprising number of different strategies to evade the immune system. Human herpesvirus...
6.
Lilley B, Ploegh H, Tirabassi R
J Virol
. 2001 Oct;
75(22):11218-21.
PMID: 11602761
Several herpesviruses encode Fc receptors that may play a role in preventing antibody-mediated clearance of the virus in vivo. Human cytomegalovirus (HCMV) induces an Fc-binding activity in cells upon infection,...
7.
Gould D, Ploegh H, Schust D
J Reprod Immunol
. 2001 Oct;
52(1-2):85-99.
PMID: 11600180
Despite immense effort, the development of vaccines effective at mucosal sites has proceeded at a faltering pace. Efforts concentrating on humoral immunity but neglecting cellular immunity may be misdirected by...
8.
Borodovsky A, Kessler B, Casagrande R, Overkleeft H, Wilkinson K, Ploegh H
EMBO J
. 2001 Sep;
20(18):5187-96.
PMID: 11566882
A C-terminally modified ubiquitin (Ub) derivative, ubiquitin vinyl sulfone (UbVS), was synthesized as an active site-directed probe that irreversibly modifies a subset of Ub C-terminal hydrolases (UCHs) and Ub-specific processing...
9.
Kessler B, Tortorella D, Altun M, Kisselev A, Fiebiger E, Hekking B, et al.
Chem Biol
. 2001 Sep;
8(9):913-29.
PMID: 11564559
Background: The 26S proteasome is responsible for most cytosolic proteolysis, and is an important protease in major histocompatibility complex class I-mediated antigen presentation. Constitutively expressed proteasomes from mammalian sources possess...
10.
Shamu C, Flierman D, Ploegh H, Rapoport T, Chau V
Mol Biol Cell
. 2001 Aug;
12(8):2546-55.
PMID: 11514634
The human cytomegalovirus protein US11 induces the dislocation of MHC class I heavy chains from the endoplasmic reticulum (ER) into the cytosol for degradation by the proteasome. With the use...