H L Ploegh
Overview
Explore the profile of H L Ploegh including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
186
Citations
7960
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
11.
Gewurz B, Gaudet R, Tortorella D, Wang E, Ploegh H
Curr Opin Immunol
. 2001 Aug;
13(4):442-50.
PMID: 11498300
Over the past year, we have witnessed the discovery of further virus immuno-evasins--proteins that alter the host immune response. Although many of these factors have been described over the past...
12.
Lennon-Dumenil A, Roberts R, Valentijn K, Driessen C, Overkleeft H, Erickson A, et al.
EMBO J
. 2001 Aug;
20(15):4055-64.
PMID: 11483509
The p41 splice variant of major histocompatibility complex (MHC) class II-associated invariant chain (Ii) contains a 65 aa segment that binds to the active site of cathepsin L (CatL), a...
13.
Driessen C, Lennon-Dumenil A, Ploegh H
Eur J Immunol
. 2001 Jul;
31(5):1592-601.
PMID: 11465117
We have analyzed the intracellular degradation of an immune complex after its FcgammaR-mediated uptake in antigen-presenting cells (APC). Mice that lack the cathepsins (Cat) S, L, B and D allowed...
14.
Maurice M, Gould D, Carroll J, Vugmeyster Y, Ploegh H
Proc Natl Acad Sci U S A
. 2001 Jun;
98(13):7437-42.
PMID: 11404484
The H-2Ld alloreactive 2C T cell receptor (TCR) is commonly considered as being positively selected on the H-2Kb molecule. Surprisingly, 2C TCR+ CD8+ single-positive T cells emerge in massive numbers...
15.
Gewurz B, Gaudet R, Tortorella D, Wang E, Ploegh H, Wiley D
Proc Natl Acad Sci U S A
. 2001 Jun;
98(12):6794-9.
PMID: 11391001
Many persistent viruses have evolved the ability to subvert MHC class I antigen presentation. Indeed, human cytomegalovirus (HCMV) encodes at least four proteins that down-regulate cell-surface expression of class I....
16.
Gewurz B, Wang E, Tortorella D, Schust D, Ploegh H
J Virol
. 2001 May;
75(11):5197-204.
PMID: 11333901
The human cytomegalovirus-encoded US2 glycoprotein targets endoplasmic reticulum-resident major histocompatibility complex (MHC) class I heavy chains for rapid degradation by the proteasome. We demonstrate that the endoplasmic reticulum-lumenal domain of...
17.
Lorenzo M, Ploegh H, Tirabassi R
Semin Immunol
. 2001 Apr;
13(1):1-9.
PMID: 11289794
Evasion of the immune system by viruses is a well-studied field. It remains a challenge to understand how these viral tactics affect pathogenesis and the viral lifecycle. At the same...
18.
Signal peptide cleavage of a type I membrane protein, HCMV US11, is dependent on its membrane anchor
Rehm A, Stern P, Ploegh H, Tortorella D
EMBO J
. 2001 Apr;
20(7):1573-82.
PMID: 11285222
The human cytomegalovirus (HCMV) US11 polypeptide is a type I membrane glycoprotein that targets major histocompatibility complex (MHC) class I molecules for destruction in a proteasome-dependent manner. Although the US11...
19.
Hsu P, Wolf Bryant P, Sutkowski N, McLellan B, Ploegh H, Huber B
J Immunol
. 2001 Feb;
166(5):3309-14.
PMID: 11207286
Mouse mammary tumor viruses encode superantigens that interact with MHC class II proteins and stimulate T cells. We show here that presentation of mouse mammary tumor virus superantigen does not...
20.
Villadangos J, Ploegh H
Immunity
. 2001 Feb;
12(3):233-9.
PMID: 10755610
Antigen-presenting cells (APC) degrade proteins intracellularly to generate peptides, which are then bound by products of the major histocompatibility complex (MHC) and exposed on the surface of the APC for...