H C Towle
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Explore the profile of H C Towle including associated specialties, affiliations and a list of published articles.
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81
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1524
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Recent Articles
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ARMSTRONG M, Towle H
Am J Physiol Endocrinol Metab
. 2001 Nov;
281(6):E1197-204.
PMID: 11701434
The discovery of homologs of the brown fat uncoupling protein(s) (UCP) UCP-2 and UCP-3 revived the hypothesis of uncoupling protein involvement in the regulation of energy metabolism. Thus we hypothesized...
3.
OCallaghan B, Koo S, Wu Y, Freake H, Towle H
J Biol Chem
. 2001 May;
276(19):16033-9.
PMID: 11340083
The rat acetyl-CoA carboxylase (ACC) alpha gene is transcribed from two promoters, denoted PI and PII, that direct regulated expression in a tissue-specific manner. Induction of ACC, the rate-controlling enzyme...
4.
Rufo C, Teran-Garcia M, Nakamura M, Koo S, Towle H, Clarke S
J Biol Chem
. 2001 Mar;
276(24):21969-75.
PMID: 11279238
Refeeding carbohydrate to fasted rats induces the transcription of genes encoding enzymes of fatty acid biosynthesis, e.g. fatty-acid synthase (FAS). Part of this transcriptional induction is mediated by insulin. An...
5.
Koo S, Dutcher A, Towle H
J Biol Chem
. 2000 Dec;
276(12):9437-45.
PMID: 11112788
Transcription of a number of genes involved in lipogenesis is stimulated by dietary carbohydrate in the mammalian liver. Both insulin and increased glucose metabolism have been proposed to be initiating...
6.
Bergad P, Schwarzenberg S, Humbert J, Morrison M, Amarasinghe S, Towle H, et al.
Am J Physiol Cell Physiol
. 2000 Nov;
279(6):C1906-17.
PMID: 11078706
Growth hormone (GH) action is attenuated during the hepatic acute-phase response (APR). To understand this attenuation, we asked whether GH and cytokine-signaling pathways intersect during an APR. In hypophysectomized rats...
7.
Kaytor E, Qian J, Towle H, Olson L
Mol Cell Biochem
. 2000 Sep;
210(1-2):13-21.
PMID: 10976753
Transcription of the L-type pyruvate kinase (L-PK) and S14 genes is induced in hepatocytes in response to increased glucose metabolism. The regulatory sequences of these genes responsible for induction by...
8.
Bergad P, Towle H, Berry S
J Biol Chem
. 2000 Mar;
275(11):8114-20.
PMID: 10713133
A growth hormone-inducible nuclear factor complex (GHINF), affinity-purified using the growth hormone response element (GHRE) from the promoter of rat serine protease inhibitor 2.1, was found to contain Stat5a and...
9.
Koo S, Towle H
J Biol Chem
. 2000 Feb;
275(7):5200-7.
PMID: 10671567
Transcription of genes encoding enzymes required for lipogenesis is induced in hepatocytes in response to elevated glucose metabolism. We have previously mapped the carbohydrate-response elements (ChoREs) of the rat liver-type...
10.
Magana M, Koo S, Towle H, Osborne T
J Biol Chem
. 2000 Feb;
275(7):4726-33.
PMID: 10671504
Sterol regulatory element-binding proteins (SREBPs) activate genes of cholesterol and fatty acid metabolism. In each case, a ubiquitous co-regulatory factor that binds to a neighboring recognition site is also required...