Gwyn T Williams
Overview
Explore the profile of Gwyn T Williams including associated specialties, affiliations and a list of published articles.
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Articles
38
Citations
1310
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Recent Articles
1.
Regulation of T-Cell Apoptosis by Sequences Encoded at the Luca-15 Candidate Tumour Suppressor Locus
Mourtada-Maarabouni M, Sutherland L, Clark J, Cooper C, Williams G
ScientificWorldJournal
. 2018 Aug;
1:38.
PMID: 30147483
No abstract available.
2.
Anderson C, Williams G
ScientificWorldJournal
. 2018 Aug;
1:33.
PMID: 30147466
No abstract available.
3.
Kizilors A, Pickard M, Schulte C, Yacqub-Usman K, McCarthy N, Gan S, et al.
Biosci Rep
. 2017 Jul;
37(4).
PMID: 28754805
The E3 ubiquitin ligase RNF168 is a ring finger protein that has previously been identified to play an important regulatory role in the repair of double-strand DNA breaks. In the...
4.
Pickard M, Williams G
Oncotarget
. 2016 Feb;
7(9):10104-16.
PMID: 26862727
Growth arrest-specific 5 (GAS5) lncRNA promotes apoptosis, and its expression is down-regulated in breast cancer. GAS5 lncRNA is a decoy of glucocorticoid/related receptors; a stem-loop sequence constitutes the GAS5 hormone...
5.
Pickard M, Williams G
Genes (Basel)
. 2015 Jul;
6(3):484-99.
PMID: 26198250
It is increasingly recognised that lncRNAs play essential regulatory roles in fundamental biological processes and, consequently, that their dysregulation may contribute to major human diseases, including cancer. Better understanding of...
6.
Yacqub-Usman K, Pickard M, Williams G
Prostate
. 2015 Feb;
75(7):693-705.
PMID: 25650269
Background: New therapies are required for castrate-resistant prostate cancer (CRPC), and growth-arrest specific 5 (GAS5) lncRNA, which riborepresses androgen receptor action, may offer novel opportunities in this regard. This lncRNA...
7.
Hudson W, Pickard M, de Vera I, Kuiper E, Mourtada-Maarabouni M, Conn G, et al.
Nat Commun
. 2014 Nov;
5:5395.
PMID: 25377354
The majority of the eukaryotic genome is transcribed, generating a significant number of long intergenic noncoding RNAs (lincRNAs). Although lincRNAs represent the most poorly understood product of transcription, recent work...
8.
Pickard M, Williams G
Breast Cancer Res Treat
. 2014 May;
145(2):359-70.
PMID: 24789445
The putative tumour suppressor and apoptosis-promoting gene, growth arrest-specific 5 (GAS5), encodes long ncRNA (lncRNA) and snoRNAs. Its expression is down-regulated in breast cancer, which adversely impacts patient prognosis. In...
9.
Mourtada-Maarabouni M, Williams G
Clin Lymphoma Myeloma Leuk
. 2014 Apr;
14(6):468-73.
PMID: 24703244
Background: Inhibition of the mammalian target of rapamycin (mTOR) pathway is a promising strategy for the treatment of mantle cell lymphoma (MCL). ncRNA growth arrest-specific 5 (GAS5), a 5' terminal...
10.
Mourtada-Maarabouni M, Williams G
Biomed Res Int
. 2013 Dec;
2013:358015.
PMID: 24319682
Nonsense-mediated decay is a key RNA surveillance mechanism responsible for the rapid degradation of mRNAs containing premature termination codons and hence prevents the synthesis of truncated proteins. More recently, it...